ArticleAmerican journal of ophthalmology2019
Earliest Evidence of Preclinical Diabetic Retinopathy Revealed Using Optical Coherence Tomography Angiography Perfused Capillary Density.
Article in American journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07641738 (Evaluation of Patients With Retinal Disorders Utilizing the XyCAM CRE Camera.), which is not on this map. Cited by 85 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Patients With Retinal Disorders Utilizing the XyCAM CRE Camera.
Who cites it
85 citing papers in PubMed, 163 citations in OpenAlex.
- Evaluating Signs of Microangiopathy Secondary to Diabetes in Different Areas of the Retina with Swept Source OCTA.Investigative ophthalmology & visual science · 2020Trial
- Individualized FAZ morphometry and standardized peri-FAZ vascular density: a pilot AngioVue OCTA study in diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Explicit Inclusion of Diabetes Mellitus Without Retinopathy Within Diabetic Retinopathy Prediction.Translational vision science & technology · 2026Article
- Foveal Density and Multi-Domain OCTA Biomarkers May Help Identify Preclinical Diabetic Microvasculopathy in Type 2 Diabetes Mellitus.Medicina (Kaunas, Lithuania) · 2026Article
- Association and Multimodal Model of Retinal Mid-Peripheral Capillary Free Zones with Structural and Functional Parameters in Diabetic Patients Without Clinical Retinopathy.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Explaining Retinal Susceptibility to Diabetes Through Photoreceptor Biology.International journal of molecular sciences · 2026Review
- Opposing end-node and junction-node remodeling patterns in diabetic patients on optical coherence tomography angiography.Scientific reports · 2026Article
- Divergent nasal-temporal changes in superficial vascular density as early biomarkers of diabetic retinopathy.BMC ophthalmology · 2026Observational
- Macular vessel density is associated with cognitive function in preclinical p.R544C NOTCH3 mutation carriers.Journal of the Chinese Medical Association : JCMA · 2025Article
- Multimodal Imaging of Diabetic Retinopathy: Insights from Optical Coherence Tomography Angiography and Adaptive Optics.Diagnostics (Basel, Switzerland) · 2025Article
- Retinal Mid-Peripheral Capillary Free Zones Are Enlarged in Diabetic Patients With No Evidence of Clinical Retinopathy.Translational vision science & technology · 2025Article
- Deep learning segmentation of periarterial and perivenous capillary-free zones in optical coherence tomography angiography.Journal of biomedical optics · 2025Article
- Volumetric Measures of Capillary Nonperfusion on Optical Coherence Tomography Angiography Detect Early Ischemia in Diabetes Without Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Retinal Biomarkers in Diabetic Retinopathy: From Early Detection to Personalized Treatment.Journal of clinical medicine · 2025Review
- Retinal Vascular Density and Thickness in Long-Term Type 1 Diabetes Without Visible Vascular Signs of Retinopathy.Journal of clinical medicine · 2025Article
- Early Diabetic Retinopathy Evaluation With OCTA: A Study on Vascular Branching and Fragmentation.Investigative ophthalmology & visual science · 2024Article
- Choriocapillaris flow deficit is associated with disease duration in type 2 diabetic patients without retinopathy: a cross-sectional study.International journal of retina and vitreous · 2024Article
- A High-Fidelity Computational Model for Predicting Blood Cell Trafficking and 3D Capillary Hemodynamics in Retinal Microvascular Networks.Investigative ophthalmology & visual science · 2024Article
- Assessing Preclinical Diabetic Retinopathy: The Role of Optical Coherence Tomography Angiography.Cureus · 2024Article
- Glycemic Control and Retinal Microvascular Changes in Type 2 Diabetes Mellitus Patients without Clinical Retinopathy.Diabetes & metabolism journal · 2024Observational
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo compare perfused capillary density (PCD) in diabetic patients and healthy controls using optical coherence tomography angiography (OCTA).
methodsForty controls, 36 diabetic subjects without clinical retinopathy (NoDR), 38 with nonproliferative retinopathy (NPDR), and 38 with proliferative retinopathy (PDR) were imaged using spectral-domain optical coherence tomography. A 3 × 3-mm full-thickness parafoveal OCTA scan was obtained from each participant. Following manual delineation of the foveal avascular zone (FAZ), FAZ area, perimeter, and acircularity index were determined. Seven consecutive equidistant 200-μm-wide annular segments were drawn at increasing eccentricities from the FAZ margin. Annular PCD (%) was defined as perfused capillary area divided by the corresponding annulus area after subtraction of noncapillary blood vessel areas. Nonparametric Kruskal-Wallis testing with Bonferroni correction was performed in pairwise comparisons of group PCD values.
resultsThe NoDR group demonstrated consistently higher PCD compared to the control group in all 7 annuli, reaching statistical significance (36.6% ± 3.30% vs 33.6% ± 3.98%, P = .034) at the innermost annulus (FAZ margin to 200 μm out). The NPDR and PDR groups demonstrated progressively decreasing PCD. Differences in FAZ metrics between the NoDR and control groups did not reach statistical significance.
conclusionsRelative to healthy controls, increased PCD values in the NoDR group likely represent an autoregulatory response to increased metabolic demand, while the decrease in PCD that follows in NPDR and PDR results largely from an incremental loss of capillary segments. These findings, consistent with previous studies, demonstrate the potential of OCTA as a clinical tool for earlier objective detection of preclinical diabetic retinopathy. NOTE: Publication of this article is sponsored by the American Ophthalmological Society.
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