ArticleJournal of experimental botany2019
The Arabidopsis AMOT1/EIN3 gene plays an important role in the amelioration of ammonium toxicity.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Phenotype Assessment and Putative Mechanisms of Ammonium Toxicity to Plants.International journal of molecular sciences · 2025Review
- Physiological, transcriptomic, and genomic analysis unravels the response of Tatary buckwheat root to high ammonium stress.Frontiers in plant science · 2025Article
- FERONIA regulates salt tolerance in Arabidopsis by controlling photorespiratory flux.The Plant cell · 2024Article
- Signaling function of NHPlanta · 2024Article
- Article
- Rewiring of primary metabolism for ammonium recycling under short-term low COFrontiers in plant science · 2024Article
- Plastid-localized amino acid metabolism coordinates rice ammonium tolerance and nitrogen use efficiency.Nature plants · 2023Article
- The TabHLH094-TaMYC8 complex mediates the cadmium response in wheat.Molecular breeding : new strategies in plant improvement · 2023Article
- Integrated comparative transcriptome and physiological analysis reveals the metabolic responses underlying genotype variations in NHFrontiers in plant science · 2023Article
- The dissection of tomato flavor: biochemistry, genetics, and omics.Frontiers in plant science · 2023Review
- TheBiology · 2022Article
- Phloem iron remodels root development in response to ammonium as the major nitrogen source.Nature communications · 2022Article
- Syringic acid from rice roots inhibits soil nitrification and NFrontiers in plant science · 2022Article
- Transcripts related with ammonium use and effects of gibberellin on expressions of the transcripts responding to ammonium in two invasive and nativeFrontiers in plant science · 2022Article
- Excessive ammonium assimilation by plastidic glutamine synthetase causes ammonium toxicity in Arabidopsis thaliana.Nature communications · 2021Article
- Arabidopsis MYB28 and MYB29 transcription factors are involved in ammonium-mediated alterations of root-system architecture.Plant signaling & behavior · 2021Article
- Diurnal dynamics of the Arabidopsis rosette proteome and phosphoproteome.Plant, cell & environment · 2021Article
- Endogenous ABA alleviates rice ammonium toxicity by reducing ROS and free ammonium via regulation of the SAPK9-bZIP20 pathway.Journal of experimental botany · 2020Article
- Overcoming Physiological Bottlenecks of Leaf Vitality and Root Development in Cuttings: A Systemic Perspective.Frontiers in plant science · 2020Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ammonium (NH4+) toxicity inhibits shoot growth in Arabidopsis, but the underlying mechanisms remain poorly characterized. Here, we show that a novel Arabidopsis mutant, ammonium tolerance 1 (amot1), exhibits enhanced shoot growth tolerance to NH4+. Molecular cloning revealed that amot1 is a new allele of EIN3, a key regulator of ethylene responses. The amot1 mutant and the allelic ein3-1 mutants show greater NH4+ tolerance than the wild type. Moreover, transgenic plants overexpressing EIN3 (EIN3ox) are more sensitive to NH4+ toxicity The ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC) increases shoot sensitivity to NH4+, whereas the ethylene perception inhibitor Ag+ decreases sensitivity. NH4+ induces ACC and ethylene accumulation. Furthermore, ethylene-insensitive mutants such as etr1-3 and ein3eil1 display enhanced NH4+ tolerance. In contrast, the ethylene overproduction mutant eto1-1 exhibits decreased ammonium tolerance. AMOT1/EIN3 positively regulates shoot ROS accumulation, leading to oxidative stress under NH4+ stress, a trait that may be related to increased expression of peroxidase-encoding genes. These findings demonstrate the role of AMOT1/EIN3 in NH4+ tolerance and confirm the strong link between NH4+ toxicity symptoms and the accumulation of hydrogen peroxide.
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