Evidence map›Paper›PMID 30689766›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019

US Guideline Criteria for Human Immunodeficiency Virus Preexposure Prophylaxis: Clinical Considerations and Caveats.

Sarah K Calabrese, Douglas S Krakower, Tiara C Willie, Trace S Kershaw, Kenneth H Mayer

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Women's Decision-Making about PrEP for HIV Prevention in Drug Treatment Contexts.Journal of the International Association of Providers of AIDS Care
    Trial
  3. Article
  4. Review
  5. Article
  6. Reimagining Preexposure Prophylaxis Provision for Women in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  7. Article
  8. Article
  9. Models of HIV Pre-Exposure Prophylaxis Care Used in Title X Family Planning Clinics in the Southern U.S.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2021
    Article
  10. Article
  11. Pre-exposure Prophylaxis Uptake and Discontinuation Among Young Black Men Who Have Sex With Men in Atlanta, Georgia: A Prospective Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The Impact of Providers as Health Discussants on Black Women's Interest in PrEP for HIV Prevention.Journal of the International Association of Providers of AIDS Care
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sarah K CalabreseDepartment of Psychology, George Washington University, Washington, DC.
Douglas S KrakowerDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard University.
Tiara C WillieMiriam Hospital.
Trace S KershawSocial and Behavioral Sciences Department, Yale School of Public Health, Yale University, New Haven, Connecticut.
Kenneth H MayerDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard University.

Funding

The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
Intervention to Promote PrEP Awareness and Equitable Prescription among ProvidersK01MH103080 · NIMH · YALE UNIVERSITY · PI CALABRESE, SARAH K. · 2014 to 2017
$634k
She's PrEPared: The Impact of Intimate Partner Violence on Women's Engagement in the PrEP Care ContinuumF31MH113508 · NIMH · YALE UNIVERSITY · PI WILLIE, TIARA C. · 2017 to 2018
$66k
NIMH NIH HHS F31 MH113508NIMH NIH HHS K01 MH103080NIMH NIH HHS R25 MH083620
6 · The paper itself

Abstract

Clinical guidelines for human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) developed by the US Centers for Disease Control and Prevention have been instrumental in the implementation of PrEP in medical practices throughout the country. However, the eligibility criteria contained within may inadvertently limit PrEP access for some patients. We describe the following key considerations and caveats related to these criteria: promotion of a selective vs universal approach to sexual health education involving PrEP; misalignment between criteria stated in the table and text boxes; problematic categorization and confounding of sexual orientation, gender identity, and risk behavior; underemphasis of network/community-level drivers of HIV transmission; oversimplification of serodiscordant risk; and lack of clarity surrounding the relevance of condoms to PrEP eligibility. We offer concrete recommendations to address the identified issues and strengthen future iterations of the guidelines, applying these recommendations in an alternative table of "criteria."

Indexed as

Practice Guidelines as TopicAnti-HIV AgentsCenters for Disease Control and Prevention, U.S.Clinical Decision-MakingCondomsFemaleHIV InfectionsHumansMalePatient CarePre-Exposure ProphylaxisRisk-TakingSexual BehaviorUnited StatesAnti-HIV Agentsclinical decision-makingHIVpatient carepreexposure prophylaxis

Identifiers

PMID30689766
PMCPMC7320075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.