ArticlePloS one2019
Health-related quality of life loss associated with first-time stroke.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07569497 (Co-design of a Physical Activity Maintenance Intervention for People With Stroke), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Co-design of a Physical Activity Maintenance Intervention for People With Stroke
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Health State Utility Values in People With Stroke: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2022Pooled it
- Cost-effectiveness of the simplified multicomponent primary care management of cardiovascular risk in Tibet, China: a within-trial and modeled economic evaluation.Journal of human hypertension · 2026Trial
- Economic Evaluation of Pre-emptive Pharmacogenetic Panel Testing versus No Genetic Testing in a Multi-ethnic Asian Population.PharmacoEconomics · 2026Article
- Co-Design of a Physical Activity Maintenance Intervention for People With Stroke: Protocol for a Mixed Methods Study.JMIR research protocols · 2026Article
- Use and Dynamic Adjustment of Self-Control Strategies in Physical Activity Engagement Among Young and Middle-Aged Stroke Patients: A Qualitative Study.Patient preference and adherence · 2026Article
- Age-specific and time-dependent trends in health-related quality of life after minor stroke: results of a cross-sectional cohort study.BMJ neurology open · 2026Article
- Health-related quality of life following lower-extremity constraint-induced movement therapy after stroke: an intervention study.Frontiers in neurology · 2026Article
- Health-Related Quality of Life in Survivors of Stroke Post Inpatient Rehabilitation Discharged to a Home Setting.Archives of rehabilitation research and clinical translation · 2025Article
- Process evaluation of a cross-sectoral, coordinated follow-up care of stroke patients: a qualitative study.Neurological research and practice · 2025Article
- Changes of health-related quality of life within 6 months after stroke by clinical and sociodemographic factors.Scientific reports · 2025Article
- Towards Proactive Recovery: A BCW Guided Nursing Intervention Protocol for Health Behavior Promotion in First-Episode Stroke Patients.Patient preference and adherence · 2025Article
- Changes in functional outcome after a first-time stroke: Data from a longitudinal study.PloS one · 2025Article
- Recovery after ischemic stroke: Effects of FuekFone home-based program on upper limb and cognitive function.International journal of nursing sciences · 2024Article
- Health-Related Quality of Life of Post-Stroke Patients in a Public Hospital.Brain & NeuroRehabilitation · 2024Article
- The relationship between self-efficacy, health literacy, and quality of life in patients with chronic diseases: a cross-sectional study in China.Frontiers in public health · 2024Article
- Using early health economic modeling to inform medical innovation development: a soft robotic sock in poststroke patients in Singapore.International journal of technology assessment in health care · 2023Article
- Functionality and quality of life in Brazilian patients 6 months post-stroke.Frontiers in neurology · 2023Article
- Repetitive Transcranial Magnetic Stimulation and Rehabilitation Therapy for Upper Limb Hemiparesis in Stroke Patients: A Narrative Review.Progress in rehabilitation medicine · 2023Review
- Cardiovascular risk factors and quality of life among stroke survivors in Korea from 2013 to 2018: a cross-sectional cohort study.Health and quality of life outcomes · 2022Article
- [Models of public care for the population with acquired brain injury in Spain: a study of the situation by Spanish autonomous communities].Revista de neurologia · 2022Article
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to quantify health-related quality of life (HRQoL) loss associated with first episode of stroke by comparing patient-reported HRQoL before and after stroke onset. The impact of stroke in local population was also evaluated by comparing the pre- and post-stroke HRQoL with that of the general population.
methodsThe HRQoL of stroke survivors was assessed with the EQ-5D-3L index score at recruitment, for recalled pre-stroke HRQoL, and at 3 and 12 month post-stroke. Change in HRQoL from pre-stroke to 3 and 12 month was self-reported by 285 and 238 patients, respectively. Mean EQ index score at each time point (baseline: 464 patients; 3 month post-stroke: 306 patients; 12 month post-stroke: 258 patients) was compared with published population norms for EQ-5D-3L.
resultsThere was a significant decrease in HRQoL at 3 (0.25) and 12 month (0.09) post-stroke when compared to the retrospectively recalled patients' mean pre-stroke HRQoL level (0.87). The reduction at 3 month was associated with the reduction in all EQ-5D-3L health dimensions; reductions remaining at 12 month were limited to dimensions of mobility, self-care, usual activities, and anxiety/depression. Stroke patients had a lower mean EQ index than the general population by 0.07 points pre-stroke (0.87 vs. 0.94), 0.33 points at 3 month (0.61 vs. 0.94) and 0.18 points at 12 month (0.76 vs. 0.94) post-stroke.
conclusionsStroke has a substantial impact on HRQoL in Singapore, especially in the first three months post-stroke. Compared to the general population, stroke survivors have lower HRQoL even before stroke onset. This pre-stroke deficit in HRQoL should be taken into account when quantifying health burden of stroke or setting goals for stroke rehabilitation.
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