Evidence map›Paper›PMID 30689574›Full record

SynthesisJournal of Alzheimer's disease : JAD2019

Impacts of Overweight and Obesity in Older Age on the Risk of Dementia: A Systematic Literature Review and a Meta-Analysis.

Isaac M Danat, Angela Clifford, Martin Partridge, Weiju Zhou, Aishat T Bakre, Anthony Chen, Danielle McFeeters, Tina Smith, Yuhui Wan, John Copeland and 2 more

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  14. Journal of neurology, neurosurgery, and psychiatry · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Isaac M DanatFaculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK.
Angela CliffordFaculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK.
Martin PartridgeFaculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK.
Weiju ZhouFaculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK.
Aishat T BakreFaculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK.
Anthony ChenFaculty of Sciences and Technology, Middlesex University, London, UK.
Danielle McFeetersFaculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK.
Tina SmithFaculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK.
Yuhui WanSchool of Public Health, Anhui Medical University, Hefei, Anhui, China.
John CopelandInstitute of Psychology, Health and Society, University of Liverpool, Liverpool, UK.
Kaarin J AnsteySchool of Psychology, University of New South Wales and Neuroscience Research Australia, Sydney, Australia.
Ruoling ChenFaculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK.
University of Wolverhampton · GBAnhui Medical University · CNMiddlesex University · GBUniversity of Liverpool · GBUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is unclear whether overweight and obesity in older age reduces or increases the risk of incident dementia.

objectiveTo assess the impacts of overweight and obesity in older age on incident dementia.

methodsWe searched cohort studies reporting body weight measured in older age and dementia through PubMed, Embase, Medline, PyschInfo, and Cochrane library until July 2016. Sixteen articles were identified for the review. We pooled data from them and a new unpublished study from China, to calculate relative risk (RR) of incident dementia in relation to body mass index (BMI) and waist circumference (WC).

resultsAll 16 cohort studies were undertaken in high income countries, with follow-up periods ranging between 3 to 18 years. Thirteen studies showed an inverse association between BMI and dementia, and three studies demonstrated a positive association. Pooled RR of dementia in relation to continuous BMI from 14 studied populations, including the new Chinese data, was 0.97 (95% CI 0.95-1.00); in those followed up <9 years it was 0.95 (0.93-0.96) while in ≥9 years follow-up it was 1.03 (0.96-1.11). In five studied populations examining categorical BMI, RR of dementia in older people classified as overweight and obese was 0.98 (0.54-1.77) and 1.17 (0.65-2.10) respectively, in comparison with other weights. The pooled WC data showed no association between increased WC and reduced risk of dementia.

conclusionThe current evidence did not support a paradox on beneficial impacts of overweight and obesity in older age on incident dementia. More studies with long term follow up are needed to clarify the association of body weight in older age with dementia risk.

Indexed as

Body Mass IndexDementiaHumansIncidenceObesityOverweightRiskWaist CircumferenceBody weightdementiameta-analysisolder people

Identifiers

PMID30689574
PMCPMC6700617
OpenAlexW2912356127

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.