Evidence map›Paper›PMID 30689549›Full record

Trial reportAging2019

Efficacy of remote ischemic conditioning on improving WMHs and cognition in very elderly patients with intracranial atherosclerotic stenosis.

Da Zhou, Jiayue Ding, Jingyuan Ya, Liqun Pan, Chaobo Bai, Jingwei Guan, Zhongao Wang, Kexin Jin, Qi Yang, Xunming Ji and 1 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06293118 (The Chronic Effect of Ischemic Conditioning on Motor Function, Cognitive Performance, and Immune System in Individuals With Parkinson's Disease), which is not on this map. Cited by 20 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 5 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06293118 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Chronic Effect of Ischemic Conditioning on Motor Function, Cognitive Performance, and Immune System in Individuals With Parkinson's Disease

TypeinterventionalSponsorHospital Israelita Albert EinsteinRan2026 to 2028Enrolled34ConditionsParkinson DiseaseArmsIschemic conditioning group, Sham group
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  3. Remote ischemic conditioning for stroke: A critical systematic review.International journal of stroke : official journal of the International Stroke Society · 2024
    Pooled it
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  5. Pooled it
  6. Trial
  7. Bioenergetics of the combat sports brain: Between risk and resilience.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  8. Review
  9. Review
  10. Article
  11. Cerebral small vessel disease: Recent advances and future directions.International journal of stroke : official journal of the International Stroke Society · 2023
    Review
  12. Review
  13. Article
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  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Da Zhou *Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jiayue Ding *Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jingyuan YaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Liqun PanDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Chaobo BaiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jingwei GuanDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Zhongao WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Kexin JinDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Qi YangDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xunming JiDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Ran MengDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNChinese Institute for Brain Research · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous study revealed that remote ischemic conditioning (RIC) reduced the incidence of stroke or TIA in octo- and nonagenarians with intracranial atherosclerotic stenosis (ICAS). Herein, we aimed to investigate whether RIC would influence the progression of white matter hyperintensities (WMHs) and cognitive impairment in the same group of patients. Fifty-eight patients with ICAS were randomly assigned in a 1:1 ratio to receive standard medical treatment with RIC (n=30) versus sham-RIC (n=28). The RIC protocol consisted of 5 cycles of alternating 5-min ischemia and 5-min reperfusion applied in the bilateral upper arms twice daily for 300 days. The efficacy outcomes included WMHs change on T2 FLAIR sequences, estimated by the Fazekas scale and Scheltens scale, cognitive change as assessed by the MMSE and MoCA, and some clinical symptoms within 300-day follow-up. Compared with the baseline, RIC treatment significantly reduced Fazekas and Scheltens scores at both 180-day (both

Indexed as

Aged, 80 and overCognitive DysfunctionFemaleHumansIschemic PreconditioningLeukoencephalopathiesMalecognitive impairmentintracranial atherosclerotic stenosisocto- and nonagenariansremote ischemic conditioningwhite matter hyperintensities

Identifiers

PMID30689549
PMCPMC6366980
OpenAlexW2914288925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.