Evidence map›Paper›PMID 30689515›Full record

ArticleHuman vaccines & immunotherapeutics2019

Genetically detoxified pertussis toxin induces superior antigen specific CD4 T cell responses compared to chemically detoxified pertussis toxin.

Naveen Surendran, Michael Pichichero

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Naveen Surendrana Center for Infectious Diseases and Immunology , Rochester General Hospital Research Institute , Rochester , NY , USA.
Michael Pichicheroa Center for Infectious Diseases and Immunology , Rochester General Hospital Research Institute , Rochester , NY , USA.
Rochester General Hospital · US

Funding

Immune potentiation to improve neonatal and pediatric vaccinesR03AI117700 · NIAID · ROCHESTER GENERAL HOSPITAL (NY) · PI SURENDRAN, NAVEEN · 2015 to 2016
$160k
NIAID NIH HHS R03 AI117700
6 · The paper itself

Abstract

Pertussis is resurgent worldwide. Currently available acellular pertussis vaccines contain chemically detoxified pertussis toxin (PTc); a highly immunogenic genetically detoxified pertussis toxin (PTg) vaccine has been off the market for over a decade. We compared CD4

Indexed as

Lymphocyte ActivationAntigens, CDAntigens, Differentiation, T-LymphocyteCD4-Positive T-LymphocytesCD69 AntigensCells, CulturedFetal BloodHumansInactivation, MetabolicInfant, NewbornInterleukin-17Lectins, C-TypeLeukocytes, MononuclearPertussis ToxinPertussis VaccineAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensIL17A protein, humanInterleukin-17Lectins, C-TypePertussis ToxinPertussis Vaccineactivation-induced marker assaygenetically detoxified pertussis toxinneonatal T cell responsepediatric vaccinesPertussis

Identifiers

PMID30689515
PMCPMC6605848
OpenAlexW2913662872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.