ArticleThe international journal of cardiovascular imaging2019
Normal values of the pulmonary artery acceleration time (PAAT) and the right ventricular ejection time (RVET) in children and adolescents and the impact of the PAAT/RVET-index in the assessment of pulmonary hypertension.
Article in The international journal of cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 27 citations in OpenAlex.
- Right Ventricular Function and Pulmonary Arterial Coupling in Paediatric Obstructive Sleep Apnea.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Early echocardiographic markers following deferred cord clamping with high or low oxygen in extremely low gestation infants (DOXIE-Echo).Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Tissue Doppler Imaging, Pulmonary Haemodynamics and Conventional Echocardiographic Indices for Early Bronchopulmonary Dysplasia Prediction in Preterm Infants: A Prospective Observational Feasibility Study.Children (Basel, Switzerland) · 2026Article
- MicroRNA profiles in preterm children with regard to BPD and echocardiographic findings.Frontiers in medicine · 2026Article
- Echocardiographic estimation of pulmonary arterial and right atrial pressures in children with congenital heart disease: a comprehensive prospective study and introduction of novel equations.Journal of cardiovascular imaging · 2024Article
- Prostaglandin-E1 infusion in persistent pulmonary hypertension of the newborn.Pediatric pulmonology · 2024Article
- Early Echocardiographic Findings of Pulmonary Hypertension-specific Therapy in Children.Medeniyet medical journal · 2023Article
- Mean pulmonary artery pressure estimated by echocardiogram rapidly exceeds 20 mmHg from the normal range in patients with connective tissue disease.Heart and vessels · 2023Article
- SCN1B Genetic Variants: A Review of the Spectrum of Clinical Phenotypes and a Report of Early Myoclonic Encephalopathy.Children (Basel, Switzerland) · 2022Review
- PATET ratio by Doppler echocardiography: noninvasive detection of pediatric pulmonary arterial hypertension.Pediatric research · 2022Review
- Article
- The association between pulmonary vascular disease and respiratory improvement in infants with type I severe bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Characterization of Cardiopulmonary Interactions and Exploring Their Prognostic Value in Acute Bronchiolitis: A Prospective Cardiopulmonary Ultrasound Study.Tomography (Ann Arbor, Mich.) · 2022Observational
- Ventricular Function and Cardio-Ankle Vascular Index in Patients With Pulmonary Artery Hypertension.Vascular health and risk management · 2022Article
- Using pulmonary artery acceleration time to evaluate pulmonary hemodynamic changes on preterm infants with respiratory distress syndrome.Translational pediatrics · 2021Article
- Downregulated developmental processes in the postnatal right ventricle under the influence of a volume overload.Cell death discovery · 2021Article
- A guide to echocardiographic assessment in children and adolescents with pulmonary hypertension.Cardiovascular diagnosis and therapy · 2021Review
- Echocardiography for the Assessment of Pulmonary Hypertension and Congenital Heart Disease in the Young.Diagnostics (Basel, Switzerland) · 2020Review
- Update on noninvasive imaging of right ventricle dysfunction in pulmonary hypertension.Cardiovascular diagnosis and therapy · 2020Review
- Left Ventricular Dysfunction and Plasmatic NT-proBNP Are Associated with Adverse Evolution in Respiratory Syncytial Virus Bronchiolitis.Diagnostics (Basel, Switzerland) · 2019Article
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Authors and funding
8 authors at 4 institutions in 1 country.
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Abstract
New echocardiographic modalities including pulmonary artery acceleration time (PAAT) and right ventricular ejection time (RVET) are evolving to facilitate an early non-invasive diagnosis for pulmonary hypertension (PH) in adults. In children, PAAT depends on age, body surface area (BSA) and heart rate (HR) and is used to predict PH. Normal values of RVET and their role to predict PH in children are still missing. PAAT/RVET-index correlates negatively with PH. We hypothesized that this index is a good predictor for PH in children and adolescents independent of age, BSA and HR and RVET is significantly reduced in PH. PAAT and RVET of 401 healthy children and 30 PH-patients were measured using pulsed-wave-Doppler. PH was diagnosed in PH-group invasively. PAAT/RVET-index for both groups was calculated. Sensitivity and specificity in prediction of PH of PAAT, PAAT z-score and PAAT/RVET-index were compared. We demonstrated normal values of RVET in children. In the healthy group, PAAT and RVET correlated significant positive to age (p < 0.001), and BSA (p < 0.001) and negative to HR (p < 0.001). PAAT/RVET-index correlated weakly to age, BSA and HR (p < 0.001). Mean pulmonary artery pressure (PAPM) ranged in the PH-group from 27 to 82 mmHg (mean 44 mmHg). In predicting PH, RVET is significantly reduced (p < 0.001). Comparing area under the curve (AUC), the difference between sensitivity and specificity of PAAT/RVET-index < 0.29 and calculated PAAT cut-off-point (87 ms) was significant (p < 0.001). Equally, AUC comparison between PAAT/RVET-index < 0.29 and PAAT z-score of - 1.33 was significant (p = 0.008). PAAT/RVET-index < 0.29 represents a good predictor of PH with a 100% sensitivity and a 95.8% specificity. PAAT/RVET-index is a simple tool and facilitates prediction of PH independent from z-scores.
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