ArticleInternational urology and nephrology2019
Associations of vitamin K status with mortality and cardiovascular events in peritoneal dialysis patients.
Article in International urology and nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04900610 (Vitamin K In PEritonial DIAlysis), which is not on this map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitamin K In PEritonial DIAlysis (VIKIPEDIA)
Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Vitamin K status and vascular calcification biomarkers as determinants of carotid plaque in peritoneal dialysis: a prospective study.Renal failure · 2026Article
- Combined Assessment of Serum dp-ucMGP and Albumin in Relation to All-Cause and Cardiovascular Mortality in Hemodialysis Patients.International journal of molecular sciences · 2026Observational
- Inactive Matrix Gla Protein and Cardiovascular Outcomes: The Multi-Ethnic Study of Atherosclerosis.Journal of the American Heart Association · 2025Article
- Vitamin K for Vascular Calcification in Kidney Patients: Still Alive and Kicking, but Still a Lot to Learn.Nutrients · 2024Review
- Development of standardized nursing terminology for the process documentation of patients with chronic kidney disease.Frontiers in nutrition · 2024Article
- Vitamin K status, all-cause mortality, and cardiovascular disease in adults with chronic kidney disease: the Chronic Renal Insufficiency Cohort.The American journal of clinical nutrition · 2022Article
- Analysis of malnutrition factors for inpatients with chronic kidney disease.Frontiers in nutrition · 2022Article
- VItamin K In PEritonial DIAlysis (VIKIPEDIA): Rationale and study protocol for a randomized controlled trial.PloS one · 2022Article
- Kidney function and cancer risk: An analysis using creatinine and cystatin C in a cohort study.EClinicalMedicine · 2021Article
- Vascular Calcification in Chronic Kidney Disease: The Role of Vitamin K- Dependent Matrix Gla Protein.Frontiers in medicine · 2020Review
- Vitamin K and vascular calcification in chronic kidney disease: An update of current evidence.Tzu chi medical journalReview
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
purposeVitamin K deficiency, expressed by a high level of desphospho-uncarboxylated matrix GLA protein (dp-ucMGP), is highly prevalent in dialysis patients. However, the predictive ability of the vitamin K status remains unclear in continuous ambulatory peritoneal dialysis (CAPD) patients.
methods158 prevalent CAPD patients with a median level of dp-ucMGP of 1093 (752, 1485) pmol/L were enrolled. Patient outcomes including all-cause mortality and cardiovascular events (CVEs) were recorded during follow-up. Survival curves were performed using Kaplan-Meier method, and the influences of dp-ucMGP on outcomes were analyzed by Cox regression models.
resultsA total of 59 deaths and 82 new episodes of CVEs occurred during median follow-up of 31.4 ± 13.1 months (range: 3.8-48.0 months). Kaplan-Meier analysis revealed patients with higher dp-ucMGP levels (≥ 1093 pmol/L) had an increased risk for both mortality (P = 0.005) and CVEs (P < 0.001). Multivariable Cox regression confirmed that higher dp-ucMGP levels increase the mortality risk [hazard ratio (HR), 1.763; 95% CI 1.045-3.291] and CVEs (HR, 1.846; 95% CI 1.074-3.172). For every 100 pmol/L increase in serum dp-ucMGP, the adjusted HRs for mortality and CVEs were 1.054 (95% CI 1.008-1.106) and 1.034 (95% CI 1.012-1.089), respectively.
conclusionsVitamin K deficiency, as expressed by high dp-ucMGP levels, showed independently associations with mortality and CVEs in CAPD patients.
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Registered trials
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