Evidence map›Paper›PMID 30689164›Full record

ArticlePathology oncology research : POR2019

N-Acetylglucosaminyltransferase III (GnT-III) but not N-Acetylgalactosaminyltransferase-6 and 8 are Differentially Expressed in Invasive and In Situ Ductal Carcinoma of the Breast.

Antônio Felix da Silva Filho, Gabriela Souto Vieira-de-Mello, Petra Barros Dos Santos, Moacyr Jesus Barreto de Melo Rêgo, Alfredo Ribeiro-Silva, Eduardo Isidoro Carneiro Beltrão

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In one paragraph

Article in Pathology oncology research : POR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Antônio Felix da Silva FilhoImmunomodulation and New Therapeutic Approaches Laboratory, Federal University of Pernambuco, Recife, Pernambuco, 50670-901, Brazil.
Gabriela Souto Vieira-de-MelloImmunomodulation and New Therapeutic Approaches Laboratory, Federal University of Pernambuco, Recife, Pernambuco, 50670-901, Brazil.
Petra Barros Dos SantosBiomarkers in cancer Laboratory, Federal University of Pernambuco, Recife, Pernambuco, 50670-901, Brazil.
Moacyr Jesus Barreto de Melo RêgoImmunomodulation and New Therapeutic Approaches Laboratory, Federal University of Pernambuco, Recife, Pernambuco, 50670-901, Brazil. moacyr.rego@gmail.com.
Alfredo Ribeiro-SilvaDepartment of Pathology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Eduardo Isidoro Carneiro BeltrãoBiomarkers in cancer Laboratory, Federal University of Pernambuco, Recife, Pernambuco, 50670-901, Brazil.
Universidade Federal de Pernambuco · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammary carcinoma is the most common malignant tumor in women, and it is the leading cause of mortality. In tumor context, glycosylation promotes post translational modifications necessary for cell progression, emerging as a relevant tumor hallmarker. This study aimed to analyze the association between polypeptide N-acetylgalactosaminyltransferase-6 (ppGalNAc-T6), -T8, N-acetylglucosaminyltransferase III (GnT-III) expression, Phaseolus vulgaris-leucoagglutinin (PHA-L), wheat germ agglutinin (WGA) and peanut agglutinin (PNA) staining with clinic-histopathological factors from patients with pure ductal carcinoma in situ (DCIS) and DCIS with invasive ductal carcinoma (DCIS-IDC) of breast. Formalin-fixed and paraffin-embedded samples (n = 109) were analyzed. In pure DCIS samples GnT-III was over-expressed in comedo lesions (p = 0.007). In DCIS-IDC, GnT-III expression was associated with high nuclear grade tumors (p = 0.039) while the presence of PHA-L and WGA were inversely related to HER-2 expression (p = 0.001; p = 0.036, respectively). These findings pointed to possible involvement of GnT-III, ppGalNAc-T8, L-PHA and WGA as probes in prognostic evaluation of DCIS.

Indexed as

AdultBiomarkers, TumorBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingFemaleHumansMiddle AgedN-Acetylglucosaminyltransferasesbeta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferaseBiomarkers, Tumormannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferaseN-AcetylglucosaminyltransferasesGlycocodeGlycosiltranferasesIn situ ductal carcinomaInvasive ductal carcinomaLectins

Identifiers

PMID30689164
OpenAlexW2911280743

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.