Evidence map›Paper›PMID 30689065›Full record

ArticleAnnals of biomedical engineering2019

Fibroblast Growth Factor-2 Binding to Heparan Sulfate Proteoglycans Varies with Shear Stress in Flow-Adapted Cells.

Jonathan Garcia, Nisha Patel, Sarah Basehore, Alisa Morss Clyne

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Preclinical techniques to investigate exercise training in vascular pathophysiology.American journal of physiology. Heart and circulatory physiology · 2021
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jonathan GarciaSchool of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut St, Philadelphia, PA, USA.
Nisha PatelSchool of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut St, Philadelphia, PA, USA.
Sarah BasehoreSchool of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut St, Philadelphia, PA, USA.
Alisa Morss ClyneMechanical Engineering and Mechanics Department, Drexel University, 3141 Chestnut St, Philadelphia, PA, USA. asm67@drexel.edu.
Drexel University · US

Funding

The effect of laminar and disturbed flow on endothelial glucose metabolismR01HL140239 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI MORSS CLYNE, ALISA S · 2018 to 2022
$1.9M
Division of Chemical, Bioengineering, Environmental, and Transport Systems CBET-0846751NHLBI NIH HHS R01 HL140239
6 · The paper itself

Abstract

Fibroblast growth factor 2 (FGF2), an important regulator of angiogenesis, binds to endothelial cell (EC) surface FGF receptors (FGFRs) and heparan sulfate proteoglycans (HSPGs). FGF2 binding kinetics have been predominantly studied in static culture; however, the endothelium is constantly exposed to flow which may affect FGF2 binding. We therefore used experimental and computational techniques to study how EC FGF2 binding changes in flow. ECs adapted to 24 h of flow demonstrated biphasic FGF2-HSPG binding, with FGF2-HSPG complexes increasing up to 20 dynes/cm

Indexed as

Models, BiologicalSignal TransductionStress, MechanicalAnimalsCells, CulturedComputer SimulationFibroblast Growth Factor 2Heparan Sulfate ProteoglycansPhosphorylationReceptors, Fibroblast Growth FactorShear StrengthSwineFibroblast Growth Factor 2Heparan Sulfate ProteoglycansReceptors, Fibroblast Growth FactorBinding kineticsEndothelial cellsFibroblast growth factor-2Fluid flowHeparan sulfate proteoglycansMass transportShear stress

Identifiers

PMID30689065
PMCPMC6470077
OpenAlexW2912194069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.