Evidence map›Paper›PMID 30688888›Full record

ArticlePlastic and reconstructive surgery2019

Injectable Allograft Adipose Matrix Supports Adipogenic Tissue Remodeling in the Nude Mouse and Human.

Lauren E Kokai, Benjamin K Schilling, Evangelia Chnari, Yen-Chen Huang, Emily A Imming, Arivarasan Karunamurthy, Roger K Khouri, Richard A D'Amico, Sydney R Coleman, Kacey G Marra and 1 more

Erratum issuedOpen access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Human Adipose Allograft Restores Volume Through Host-mediated Tissue Replacement.Plastic and reconstructive surgery. Global open · 2026
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  15. Allograft Adipose Matrix: A New Natural Approach With Evidence for 8-Year Longevity of Soft Tissue Augmentation.Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Lauren E KokaiFrom the Department of Plastic Surgery, School of Medicine, McGowan Institute of Regenerative Medicine, and Department of Bioengineering, University of Pittsburgh; the Departments of Pathology and Dermatology, University of Pittsburgh Medical Center; the Musculoskeletal Transplant Foundation; Florida International University; Miami Breast Center; the Department of Plastic Surgery, Mount Sinai School of Medicine; The Hansjorg Wyss Department of Plastic Surgery, School of Medicine, New York University; and TriBeCa Plastic Surgery.
Benjamin K SchillingFrom the Department of Plastic Surgery, School of Medicine, McGowan Institute of Regenerative Medicine, and Department of Bioengineering, University of Pittsburgh; the Departments of Pathology and Dermatology, University of Pittsburgh Medical Center; the Musculoskeletal Transplant Foundation; Florida International University; Miami Breast Center; the Department of Plastic Surgery, Mount Sinai School of Medicine; The Hansjorg Wyss Department of Plastic Surgery, School of Medicine, New York University; and TriBeCa Plastic Surgery.
Evangelia ChnariFrom the Department of Plastic Surgery, School of Medicine, McGowan Institute of Regenerative Medicine, and Department of Bioengineering, University of Pittsburgh; the Departments of Pathology and Dermatology, University of Pittsburgh Medical Center; the Musculoskeletal Transplant Foundation; Florida International University; Miami Breast Center; the Department of Plastic Surgery, Mount Sinai School of Medicine; The Hansjorg Wyss Department of Plastic Surgery, School of Medicine, New York University; and TriBeCa Plastic Surgery.
Yen-Chen HuangFrom the Department of Plastic Surgery, School of Medicine, McGowan Institute of Regenerative Medicine, and Department of Bioengineering, University of Pittsburgh; the Departments of Pathology and Dermatology, University of Pittsburgh Medical Center; the Musculoskeletal Transplant Foundation; Florida International University; Miami Breast Center; the Department of Plastic Surgery, Mount Sinai School of Medicine; The Hansjorg Wyss Department of Plastic Surgery, School of Medicine, New York University; and TriBeCa Plastic Surgery.
Emily A ImmingFrom the Department of Plastic Surgery, School of Medicine, McGowan Institute of Regenerative Medicine, and Department of Bioengineering, University of Pittsburgh; the Departments of Pathology and Dermatology, University of Pittsburgh Medical Center; the Musculoskeletal Transplant Foundation; Florida International University; Miami Breast Center; the Department of Plastic Surgery, Mount Sinai School of Medicine; The Hansjorg Wyss Department of Plastic Surgery, School of Medicine, New York University; and TriBeCa Plastic Surgery.
Arivarasan KarunamurthyFrom the Department of Plastic Surgery, School of Medicine, McGowan Institute of Regenerative Medicine, and Department of Bioengineering, University of Pittsburgh; the Departments of Pathology and Dermatology, University of Pittsburgh Medical Center; the Musculoskeletal Transplant Foundation; Florida International University; Miami Breast Center; the Department of Plastic Surgery, Mount Sinai School of Medicine; The Hansjorg Wyss Department of Plastic Surgery, School of Medicine, New York University; and TriBeCa Plastic Surgery.
Roger K KhouriFrom the Department of Plastic Surgery, School of Medicine, McGowan Institute of Regenerative Medicine, and Department of Bioengineering, University of Pittsburgh; the Departments of Pathology and Dermatology, University of Pittsburgh Medical Center; the Musculoskeletal Transplant Foundation; Florida International University; Miami Breast Center; the Department of Plastic Surgery, Mount Sinai School of Medicine; The Hansjorg Wyss Department of Plastic Surgery, School of Medicine, New York University; and TriBeCa Plastic Surgery.
Richard A D'AmicoFrom the Department of Plastic Surgery, School of Medicine, McGowan Institute of Regenerative Medicine, and Department of Bioengineering, University of Pittsburgh; the Departments of Pathology and Dermatology, University of Pittsburgh Medical Center; the Musculoskeletal Transplant Foundation; Florida International University; Miami Breast Center; the Department of Plastic Surgery, Mount Sinai School of Medicine; The Hansjorg Wyss Department of Plastic Surgery, School of Medicine, New York University; and TriBeCa Plastic Surgery.
Sydney R ColemanFrom the Department of Plastic Surgery, School of Medicine, McGowan Institute of Regenerative Medicine, and Department of Bioengineering, University of Pittsburgh; the Departments of Pathology and Dermatology, University of Pittsburgh Medical Center; the Musculoskeletal Transplant Foundation; Florida International University; Miami Breast Center; the Department of Plastic Surgery, Mount Sinai School of Medicine; The Hansjorg Wyss Department of Plastic Surgery, School of Medicine, New York University; and TriBeCa Plastic Surgery.
Kacey G MarraFrom the Department of Plastic Surgery, School of Medicine, McGowan Institute of Regenerative Medicine, and Department of Bioengineering, University of Pittsburgh; the Departments of Pathology and Dermatology, University of Pittsburgh Medical Center; the Musculoskeletal Transplant Foundation; Florida International University; Miami Breast Center; the Department of Plastic Surgery, Mount Sinai School of Medicine; The Hansjorg Wyss Department of Plastic Surgery, School of Medicine, New York University; and TriBeCa Plastic Surgery.
J Peter RubinFrom the Department of Plastic Surgery, School of Medicine, McGowan Institute of Regenerative Medicine, and Department of Bioengineering, University of Pittsburgh; the Departments of Pathology and Dermatology, University of Pittsburgh Medical Center; the Musculoskeletal Transplant Foundation; Florida International University; Miami Breast Center; the Department of Plastic Surgery, Mount Sinai School of Medicine; The Hansjorg Wyss Department of Plastic Surgery, School of Medicine, New York University; and TriBeCa Plastic Surgery.
Young Invincibles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdipose tissue reaches cellular stasis after puberty, leaving adipocytes unable to significantly expand or renew under normal physiologic conditions. This is problematic in progressive lipodystrophies, in instances of scarring, and in soft-tissue damage resulting from lumpectomy and traumatic deformities, because adipose tissue will not self-renew once damaged. This yields significant clinical necessity for an off-the-shelf de novo soft-tissue replacement mechanism.

methodsA process comprising separate steps of removing lipid and cellular materials from adipose tissue has been developed, creating an ambient temperature-stable allograft adipose matrix. Growth factors and matrix proteins relevant to angiogenesis and adipogenesis were identified by enzyme-linked immunosorbent assay and immunohistochemistry, and subcutaneous soft-tissue integration of the allograft adipose matrix was investigated in vivo in both the athymic mouse and the dorsum of the human wrist.

resultsAllograft adipose matrix maintained structural components and endogenous growth factors. In vitro, adipose-derived stem cells cultured on allograft adipose matrix underwent adipogenesis in the absence of media-based cues. In vivo, animal modeling showed vasculature formation followed by perilipin A-positive tissue segments. Allograft adipose matrix maintained soft-tissue volume in the dorsal wrist in a 4-month investigation with no severe adverse events, becoming palpably consistent with subcutaneous adipose.

conclusionsSubcutaneous implantation of allograft adipose matrix laden with retained angiogenic and adipogenic factors served as an inductive scaffold for sustaining adipogenesis. Tissue incorporation assessed histologically from both the subcutaneous injection site of the athymic nude mouse over 6 months and human dorsal wrist presented adipocyte morphology residing within the injected scaffold.

Indexed as

AdipocytesAdipogenesisAdipose TissueAnimalsBiopsy, NeedleExtracellular MatrixHumansImmunohistochemistryInjections, SubcutaneousMiceMice, NudeModels, AnimalNeovascularization, PhysiologicRejuvenationStem Cell TransplantationTissue Engineering

Identifiers

PMID30688888
PMCPMC6358185
OpenAlexW2943131346

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.