Evidence map›Paper›PMID 30688770›Full record

ArticlePsychosomatic medicine2019

Psychological Traits, Heart Rate Variability, and Risk of Coronary Heart Disease in Healthy Aging Women-The Women's Health Initiative.

Elena Salmoirago-Blotcher, Kathleen M Hovey, Cristopher A Andrews, Matthew Allison, Robert L Brunner, Nathalie L Denburg, Charles Eaton, Lorena Garcia, Shawnita M Sealy-Jefferson, Oleg Zaslavsky and 5 more

Abstract read
In one paragraph

Article in Psychosomatic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Elena Salmoirago-BlotcherFrom the The Miriam Hospital (Salmoirago-Blotcher); Brown University School of Medicine (Salmoirago-Blotcher, Eaton), Providence, Rhode Island; University at Buffalo (Hovey), Buffalo, New York; University of Michigan (Andrews), Ann Arbor, Michigan; UC San Diego (Allison), La Jolla, California; University of Nevada (Brunner), Reno, Nevada; University of Iowa (Denburg), Iowa City, Iowa; Brown University School of Medicine and School of Public Health (Eaton), Providence, Rhode Island; UC Davis (Garcia), Davis, California; Ohio State University (Sealy-Jefferson), Columbus, Ohio; University of Washington (Zaslavsky), Seattle, Washington; Northwestern University (former affiliation), Evanston, Illinois; US Centers for Disease Control and Prevention (Kang), Atlanta, Georgia; UC San Francisco (López), San Francisco, California; Stony Brook University (Post), Stony Brook, New York; Vanderbilt University (Tindle), Nashville, Tennessee; and Albert Einstein College of Medicine (Wassertheil-Smoller), New York, New York.
Kathleen M Hovey
Cristopher A Andrews
Matthew Allison
Robert L Brunner
Nathalie L Denburg
Charles Eaton
Lorena Garcia
Shawnita M Sealy-Jefferson
Oleg Zaslavsky
Joseph Kang
Lenny López
Stephen G Post
Hilary Tindle
Sylvia Wassertheil-Smoller
Stony Brook University Hospital · USUniversity of Michigan · US

Funding

WOMENS HEALTH INITIATIVE-N01WH22110N01WH022110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ROSS, PRENTICE · 1992 to 2006
$1.2M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032119 · WH · MEMORIAL HOSPITAL OF RHODE ISLAND · PI ASSAF, ANNLOUISE R. · 1993 to 2000
$1.2M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032118 · WH · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JOHNSON, KAREN C · 1993 to 2000
$992k
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032122 · WH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI TREVISAN, MAURIZIO · 1993 to 2000
$927k
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032115 · WH · UNIVERSITY OF ARIZONA · PI BASSFORD, TAMSEN E · 1993 to 2000
$196k
NHLBI NIH HHS N01 WH032118WHI NIH HHS N01 WH022110WHI NIH HHS N01 WH024152WHI NIH HHS N01 WH032115WHI NIH HHS N01 WH032119WHI NIH HHS N01 WH032122WHI NIH HHS N01 WH044221
6 · The paper itself

Abstract

objectivePsychological traits such as optimism and hostility affect coronary heart disease (CHD) risk, but mechanisms for this association are unclear. We hypothesized that optimism and hostility may affect CHD risk via changes in heart rate variability (HRV).

methodsWe conducted a longitudinal analysis using data from the Women's Health Initiative Myocardial Ischemia and Migraine Study. Participants underwent 24-hour ambulatory electrocardiogram monitoring 3 years after enrollment. Optimism (Life Orientation Test-Revised), cynical hostility (Cook-Medley), demographics, and coronary risk factors were assessed at baseline. HRV measures included standard deviation of average N-N intervals (SDNN); standard deviation of average N-N intervals for 5 minutes (SDANN); and average heart rate (HR). CHD was defined as the first occurrence of myocardial infarction, angina, coronary angioplasty, and bypass grafting. Linear and Cox regression models adjusted for CHD risk factors were used to examine, respectively, associations between optimism, hostility, and HRV and between HRV and CHD risk.

resultsFinal analyses included 2655 women. Although optimism was not associated with HRV, hostility was inversely associated with HRV 3 years later (SDANN: adjusted β = -0.54; 95% CI = -0.97 to -0.11; SDNN: -0.49; 95% CI = -0.93 to -0.05). HRV was inversely associated with CHD risk; for each 10-millisecond increase in SDNN or SDANN, there was a decrease in CHD risk of 9% (p = .023) and 12% (p = .006), respectively.

conclusionsHRV did not play a major role in explaining why more optimistic women seem to be somewhat protected from CHD risk. Although hostility was inversely associated with HRV, its role in explaining the association between hostility and CHD risk remains to be established.

Indexed as

AgingCoronary DiseaseHostilityOptimismPersonalityAgedFemaleHumansMiddle AgedProspective StudiesRisk Factors

Identifiers

PMID30688770
PMCPMC6443472
OpenAlexW2911259052

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.