ArticleAnnals of surgery2020
Prospective Validation of a Transcriptomic Metric in Severe Trauma.
Open access · greenAbstract readValidation Study
In one paragraph
Article in Annals of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial.Journal of translational medicine · 2025Trial
- Analysis of the Plasma Metabolome after Trauma, Novel Circulating Sphingolipid Signatures, and In-Hospital Outcomes.Journal of the American College of Surgeons · 2021Trial
- Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma.Nature communications · 2020Trial
- Utilizing predictive machine-learning modelling unveils feature-based risk assessment system for hyperinflammatory patterns and infectious outcomes in polytrauma.Frontiers in immunology · 2023Article
- Lipidomic signatures align with inflammatory patterns and outcomes in critical illness.Nature communications · 2022Article
- Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients.Metabolites · 2022Article
- Chronic Critical Illness Elicits a Unique Circulating Leukocyte Transcriptome in Sepsis Survivors.Journal of clinical medicine · 2021Article
- Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury.Mediators of inflammation · 2021Article
- Iodine Redistribution During Trauma, Sepsis, and Hibernation: An Evolutionarily Conserved Response to Severe Stress.Critical care explorations · 2020Article
- Observational
- Immunological Endotyping of Chronic Critical Illness After Severe Sepsis.Frontiers in medicine · 2020Review
- Machine learning for the detection of early immunological markers as predictors of multi-organ dysfunction.Scientific data · 2019Article
- Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma.Scientific reports · 2019Article
- Diagnosing and Managing Sepsis by Probing the Host Response to Infection: Advances, Opportunities, and Challenges.Journal of clinical microbiology · 2019Review
Corrections and comments
- Commented on by
Authors and funding
18 authors at 5 institutions in 1 country.
Steven L RaymondDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL.
Russell B HawkinsDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL.
Zhongkai WangDepartment of Biostatistics, University of Florida College of Medicine, Gainesville, FL.
Juan C MiraDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL.
Julie A StortzDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL.
Feifei HanDepartment of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Jennifer D LanzDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL.
Laura V HennessyDepartment of Surgery, Harborview Medical Center, University of Washington, Seattle, WA.
Babette A BrumbackDepartment of Biostatistics, University of Florida College of Medicine, Gainesville, FL.
Henry V BakerDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL.
Philip A EfronDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL.
Scott C BrakenridgeDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL.
Wenzhong XiaoDepartment of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Ronald G TompkinsDepartment of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Joseph CuschieriDepartment of Surgery, Harborview Medical Center, University of Washington, Seattle, WA.
Frederick A MooreDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL.
Ronald V MaierDepartment of Surgery, Harborview Medical Center, University of Washington, Seattle, WA.
Lyle L MoldawerDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL.
University of Florida · USFlorida College · USHarvard University · USHarborview Medical Center · USUniversity of Washington · US
Funding
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8MVIRAL VECTOR DELIVERY OF ANTISENSE TO ACE MRNA IN CARDIOVASCULAR DISEASEP01HL059412 · NHLBI · UNIVERSITY OF FLORIDA · PI MUZYCZKA, NICHOLAS · 1998 to 2012
$20.2MPICS: A New Horizon for Surgical Critical CareP50GM111152 · NIGMS · UNIVERSITY OF FLORIDA · PI MOORE, FREDERICK A · 2014 to 2018
$10.7MMolecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0MVIRAL VECTOR DELIVERY OF ANTISENSE TO ACE MRNA IN CARDIOVASCULAR DISEASEP50HL059412 · NHLBI · UNIVERSITY OF FLORIDA · PI MUZYCZKA, NICHOLAS · 1997 to 2001
$3.0MREGULATION ON MONOKINE PRODUCTION IN TRAUMA AND SURGERYR01GM040586 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI MOLDAWER, LYLE L · 1988 to 2016
$2.6MNovel Mechanisms and Approaches to Treat Neonatal SepsisR01GM097531 · NIGMS · UNIVERSITY OF FLORIDA · PI LARSON, SHAWN DAVID, MOLDAWER, LYLE L · 2011 to 2018
$2.3MCYTOKINE REGULATION IN SEPSIS/INFLAMMATIONR37GM040586 · NIGMS · UNIVERSITY OF FLORIDA · PI MOLDAWER, LYLE L · 1998 to 2007
$2.3MTargeted Interleukin-10 Gene Therapy in Sepsis SyndromesR01GM063041 · NIGMS · UNIVERSITY OF FLORIDA · PI MOLDAWER, LYLE L · 2001 to 2008
$2.2MValidation of a Genomics Based Prognostic in Severe TraumaR01GM104481 · NIGMS · UNIVERSITY OF FLORIDA · PI MOLDAWER, LYLE L · 2013 to 2016
$1.8MMyeloid Suppressor Cells in Sepsis and TraumaR01GM081923 · NIGMS · UNIVERSITY OF FLORIDA · PI MOLDAWER, LYLE L · 2008 to 2014
$1.8MHematopoietic Stem Cell Dysfunction in the Elderly after Severe InjuryR01GM113945 · NIGMS · UNIVERSITY OF FLORIDA · PI EFRON, PHILIP A · 2015 to 2019
$1.6MNHLBI NIH HHS P01 HL059412NHLBI NIH HHS P50 HL059412NIA NIH HHS P30 AG028740NIDDK NIH HHS R01 DK091443NIGMS NIH HHS P50 GM111152NIGMS NIH HHS R01 GM040586NIGMS NIH HHS R01 GM063041NIGMS NIH HHS R01 GM081923NIGMS NIH HHS R01 GM097531NIGMS NIH HHS R01 GM104481NIGMS NIH HHS R01 GM113945NIGMS NIH HHS R37 GM040586NIGMS NIH HHS T32 GM008721
Abstract
PubMed holds no abstract for this paper.
Indexed as
BiomarkersFemaleHospital MortalityHumansInjury Severity ScoreInterleukin-6LeukocytesMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentSurvival AnalysisTranscriptomeTrauma CentersBiomarkersInterleukin-6
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.