Evidence map›Paper›PMID 30688408›Full record

ArticleCurrent protocols in nucleic acid chemistry2019

Facile Modifications at the C4 Position of Pyrimidine Nucleosides via In Situ Amide Activation with 1H-Benzotriazol-1-yloxy-tris(dimethyl-amino)phosphonium Hexafluorophosphate.

Hari K Akula, Mahesh K Lakshman

Abstract read
In one paragraph

Article in Current protocols in nucleic acid chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hari K AkulaDepartment of Chemistry and Biochemistry, The City College of New York, New York, New York.
Mahesh K LakshmanDepartment of Chemistry and Biochemistry, The City College of New York, New York, New York.

Funding

Cellular/Molecular Basis of Development: Research CenterG12MD007603 · NIMHD · CITY COLLEGE OF NEW YORK · PI PEZZANO, MARK · 2012 to 2017
$11.5M
NIMHD NIH HHS G12 MD007603
6 · The paper itself

Abstract

Two approaches for C4 modifications of silyl-protected thymidine, 2'-deoxyuridine, and 3'-azido-2',3'-dideoxythymidine (AZT) are described. In both, nucleoside amide activation with 1H-benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and DBU yields O

Indexed as

AmidesCarbon-13 Magnetic Resonance SpectroscopyChromatography, GelChromatography, Thin LayerFluoridesPhosphatesProton Magnetic Resonance SpectroscopyPyrimidine NucleosidesSpectrometry, Mass, Electrospray IonizationSpectrophotometry, UltravioletAmidesFluoridesfluorophosphatePhosphatesPyrimidine Nucleosides1H-benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP)2′-deoxyuridine3′-azido-2′,3′-dideoxythymidine (AZT)amide activationnucleoside modificationpyrimidine nucleosidesthymidine

Identifiers

PMID30688408
PMCPMC6834435

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.