Evidence map›Paper›PMID 30688291›Full record

ArticleJournal of visualized experiments : JoVE2019

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells.

Shino Mitsunaga, Keiko Shioda, Kurt J Isselbacher, Jacob H Hanna, Toshi Shioda

Open access · bronzeAbstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Shino MitsunagaCenter for Cancer Research, Massachusetts General Hospital.
Keiko ShiodaCenter for Cancer Research, Massachusetts General Hospital.
Kurt J IsselbacherCenter for Cancer Research, Massachusetts General Hospital.
Jacob H HannaDepartment of Molecular Genetics, Weizmann Institute of Science.
Toshi ShiodaCenter for Cancer Research, Massachusetts General Hospital; TSHIODA@mgh.harvard.edu.
Center for Cancer Research · USWeizmann Institute of Science · IL

Funding

Transgenerational obesity caused by ancestral exposure to obesogens in utero: changes in germline genomic architecture, roles of gonadal somatic cells, and metabolomic analysis of sexual dimorphismR01ES023316 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRUCE BLUMBERG, TOSHIHIRO SHIODA · 2013 to 2026
$8.3M
Roles of Nuclear Receptors in Generation of Heritable Epimutations in Germ CellsR21ES024861 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI SHIODA, TOSHIHIRO · 2015 to 2016
$471k
NIEHS NIH HHS R01 ES023316NIEHS NIH HHS R21 ES024861
6 · The paper itself

Abstract

Primordial germ cells (PGCs) are common precursors of all germline cells. In mouse embryos, a founding population of ~40 PGCs are induced from pluripotent epiblast cells by orchestrated exposures to cytokines, including bone morphogenetic protein 4 (Bmp4). In human embryos, the earliest PGCs have been identified on the endodermal wall of yolk sac around the end of the 3

Indexed as

Cell Culture TechniquesCell DifferentiationCells, CulturedCellular ReprogrammingEmbryoid BodiesGerm CellsHumansInduced Pluripotent Stem CellsOctamer Transcription Factor-3Octamer Transcription Factor-3POU5F1 protein, human

Identifiers

PMID30688291
PMCPMC11832224
OpenAlexW2910136331

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.