Evidence map›Paper›PMID 30688088›Full record

ReviewNutrition and cancer2019

Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review.

Julia E Inglis, Po-Ju Lin, Sarah L Kerns, Ian R Kleckner, Amber S Kleckner, Daniel A Castillo, Karen M Mustian, Luke J Peppone

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition and cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 10 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 10 syntheses or guidelines pooled it, 130 citations in OpenAlex.

  1. Pooled it
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  8. Risk factors for cancer-related fatigue in patients with colorectal cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
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  11. Trial
  12. The effect of ginseng extract on fatigue in cancer survivors: a randomized double-blind clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  13. Time-restricted eating to address persistent cancer-related fatigue among cancer survivors: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  20. Recent advances in understanding chemotherapy-induced fatigue in BC patients residing in high-altitude regions: a review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Julia E Inglisa Department of Surgery , University of Rochester Medical Center (URMC) , Rochester , New York , USA.ORCID 0000-0001-8236-0840
Po-Ju Lina Department of Surgery , University of Rochester Medical Center (URMC) , Rochester , New York , USA.
Sarah L Kernsb Department of Radiation Oncology , University of Rochester Medical Center (URMC) , Rochester , New York , USA.
Ian R Klecknera Department of Surgery , University of Rochester Medical Center (URMC) , Rochester , New York , USA.
Amber S Klecknera Department of Surgery , University of Rochester Medical Center (URMC) , Rochester , New York , USA.
Daniel A Castilloc Edward G. Miner Library, University of Rochester Medical Center (URMC) , Rochester , New York , USA.
Karen M Mustiana Department of Surgery , University of Rochester Medical Center (URMC) , Rochester , New York , USA.
Luke J Pepponea Department of Surgery , University of Rochester Medical Center (URMC) , Rochester , New York , USA.
University of Rochester Medical Center · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Cancer Control Research Training Curriculum (R25T)R25CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C, MORROW, GARY R · 2004 to 2018
$6.7M
The Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy, Inflammation, and Interoceptive Brain CircuitryK07CA221931 · NCI · UNIVERSITY OF ROCHESTER · PI KLECKNER, IAN ROBERT · 2018 to 2022
$795k
Risk Prediction for Development of Adverse Effects FOllowing Radiotherapy for Prostate CancerK07CA187546 · NCI · UNIVERSITY OF ROCHESTER · PI KERNS, SARAH L. · 2015 to 2019
$649k
NCI NIH HHS K07 CA187546NCI NIH HHS K07 CA221931NCI NIH HHS R25 CA102618NCI NIH HHS UG1 CA189961
6 · The paper itself

Abstract

Cancer-related fatigue (CRF) is a debilitating syndrome that persists for many cancer survivors for years after treatment. Symptoms include early and persistent fatigue, functional decline, depression, and cognitive difficulties. Inflammation, assessed using pro-inflammatory biomarkers, is increased in cancer survivors with fatigue and treatments for fatigue are often aimed at reducing inflammation. Additionally, cancer and its treatment lead to nutritional complications, changes in body composition, and nutritional deficiencies that potentially weaken the cancer survivor and impact CRF. We conducted a qualitative review of clinical trials that assessed nutritional interventions for preventing and treating CRF. Further studies were examined that used nutritional interventions to address inflammation and fatigue, due to the dearth of nutrition research directly related to CRF. Dietary intake prior to, during, and after cancer treatment appears to affect fatigue levels. Increased protein intake may help preserve lean mass and body composition. Dietary patterns that reduce inflammation, such as the Mediterranean diet and other plant-based diets, appear tolerable to cancer survivors and may reduce fatigue. Supplementation with ginseng, ginger, or probiotics may improve cancer survivors' energy levels. Nutritional interventions, alone or in combination with other interventions should be considered as therapy for fatigue in cancer survivors.

Indexed as

Cancer SurvivorsClinical Trials as TopicDietDietary SupplementsFatigueGastrointestinal MicrobiomeHumansMicronutrientsNeoplasmsNutrientsNutrition TherapyProbioticsMicronutrientsNutrients

Identifiers

PMID30688088
PMCPMC6456409
OpenAlexW2911885342

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.