Evidence map›Paper›PMID 30687948›Full record

ArticleMagnetic resonance in medicine2019

Dynamic metabolic imaging of copolarized [2-

Maninder Singh, Sonal Josan, Minjie Zhu, Aditya Jhajharia, Dirk Mayer

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Maninder SinghDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland.ORCID 0000-0001-9212-6361
Sonal JosanSiemens Healthcare, Erlangen, Germany.
Minjie ZhuDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland.
Aditya JhajhariaDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland.
Dirk MayerDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland.ORCID 0000-0001-7557-9019
University of Maryland, Baltimore · USSiemens Healthineers (Germany) · DE

Funding

Metabolic imaging of nonalcoholic fatty liver diseaseR01DK106395 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK · 2016 to 2019
$1.9M
Dynamic Metabolic Imaging of Hyperpolarized SubstratesR01EB009070 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK · 2009 to 2012
$1.6M
Metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized 13C pyruvateR21NS096575 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK · 2016 to 2017
$424k
Hyperpolarized 13C imaging of mitochondrial metabolism for improved characterization of prostate cancerR21CA213020 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK, SIDDIQUI, MOHUMMAD MINHAJ · 2017 to 2018
$369k
Exploiting Altered Porphyrin Synthesis for Metabolic Imaging of GlioblastomaR21CA202694 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI KAO, JOSEPH PAO YUNG, MAYER, DIRK · 2016 to 2017
$369k
NCI NIH HHS R21 CA202694NCI NIH HHS R21 CA213020NIBIB NIH HHS R01 EB009070NIDDK NIH HHS R01 DK106395NIH HHS R01 DK106395NIH HHS R21 CA202694NIH HHS R21 CA213020NIH HHS R21 NS096575.NINDS NIH HHS R21 NS096575
6 · The paper itself

Abstract

purposeDeveloping a method for simultaneous metabolic imaging of copolarized [2-

methodsThe proposed pulse sequence consists of 2 frequency-selective radiofrequency pulses to alternatingly excite 2 spectral sub-bands each one followed by a fast 3D spiral CSI (3D-spCSI) readout. Spectrally selective radiofrequency pulses were designed to excite differential flip angles on substrates and products in each spectral sub-band. Number of signal averages analysis was used to determine a spectral width suitable to resolve the metabolites of interest in each of the sub-bands.

resultsPhantom experiments verified the copolarization strategy and radiofrequency pulse design following differential flip angle used in our method. The signal behavior of the resonances in each sub-band was unaffected by the excitation of the respective alternate frequency band. Dynamic 3D

conclusionThe presented method allows the dynamic CSI of a mixture of [2-

Indexed as

Magnetic Resonance ImagingMagnetic Resonance SpectroscopyAnimalsArtifactsCarbon IsotopesFumaratesImaging, Three-DimensionalLiverMaleNormal DistributionPhantoms, ImagingPyruvic AcidRadio WavesRatsRats, WistarSignal Processing, Computer-AssistedCarbon IsotopesFumaratesPyruvic Acid[1,4-13C2]fumarate[2-13C]pyruvatedynamic metabolic imaginghyperpolarized 13Cliver

Identifiers

PMID30687948
PMCPMC6414264
OpenAlexW2913429534

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.