Evidence map›Paper›PMID 30687942›Full record

ArticleMagnetic resonance in medicine2019

Chemical exchange saturation transfer imaging of phosphocreatine in the muscle.

Julius Juhyun Chung, Tao Jin, Jung Hee Lee, Seong-Gi Kim

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 61 citations in OpenAlex.

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  11. Quantitative Assessment of Peripheral Oxidative Metabolism With a New DynamicJournal of magnetic resonance imaging : JMRI · 2024
    Article
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  16. Creatine mapping of the brain at 3T by CEST MRI.Magnetic resonance in medicine · 2024
    Article
  17. Dual contrast CEST MRI for pH-weighted imaging in stroke.Magnetic resonance in medicine · 2024
    Article
  18. Article
  19. Biogenic Imaging Contrast Agents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  20. The exchange rate of creatine CEST in mouse brain.Magnetic resonance in medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Julius Juhyun ChungCenter for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea.
Tao JinDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jung Hee LeeCenter for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea.
Seong-Gi KimCenter for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea.
Samsung (South Korea) · KRUniversity of Pittsburgh · US

Funding

Magnetic Resonance Imaging of Glucose Analogs in StrokeR01NS100703 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JIN, TAO · 2018 to 2022
$1.6M
NINDS NIH HHS R01 NS100703
6 · The paper itself

Abstract

purposeTo determine the exchange parameters for the CEST of phosphocreatine (PCrCEST) in phantoms and to characterize PCrCEST in vivo in the muscle at different saturation powers and magnetic fields.

methodsExchange parameters were measured in PCr solutions using varying saturation power at 15.2 T. Z-spectra were analyzed using multipool Lorentzian fitting in the hindlimb using various powers at 2 different fields: 9.4 T and 15.2 T. Modulation of PCr signal in PCrCEST and phosphorus MRS was observed in the mouse hindlimb before and after euthanasia.

resultsThe exchange rate of PCr at physiological pH in phantoms was confirmed to be in a much slower exchange regime compared with Cr: k

conclusionThe PCrCEST technique has viable sensitivity in the muscle at high fields and shows promise for the study of metabolic dysfunction and cardiac systems.

Indexed as

AnimalsHindlimbImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMuscle, SkeletalPhantoms, ImagingPhosphocreatinePhosphocreatineCESTchemical exchangecreatinephosphocreatineultrahigh field

Identifiers

PMID30687942
PMCPMC6435392
OpenAlexW2911660488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.