ArticleBioMed research international2018
Effect of Hemiepiphysiodesis on the Growth Plate: The Histopathological Changes and Mechanism Exploration of Recurrence in Mini Pig Model.
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Percutaneous epiphysiodesis transphyseal screw versus tension-band plating as hemiepiphysiodesis in treating coronal angular knee deformities: a systematic review and meta-analysis of comparative studies.BMC musculoskeletal disorders · 2025Pooled it
- Rebound After Guided Growth for Idiopathic Genu Valgum: Long-Term Radiographic Follow-Up to Skeletal Maturity and Associated Factors.Journal of clinical medicine · 2026Article
- Exploring the impact of mechanical stimuli on growth plate morphology and trabecular adaptation: A finite element approach.Journal of orthopaedics · 2025Article
- The efficacy of physeal bar resection with guided growth in the treatment of physeal arrest with angular limb deformity.Scientific reports · 2024Article
- Operative Management of Pediatric Physeal Bar Development and Genu Valgum.Orthopedic reviews · 2024Article
- Natural behaviours after guided growth for idiopathic genu valgum correction: comparison between percutaneous transphyseal screw and tension-band plate.BMC musculoskeletal disorders · 2022Article
- Rebound phenomenon and its risk factors after hemiepiphysiodesis using tension band plate in children with coronal angular deformity.BMC musculoskeletal disorders · 2022Article
- Comparison of histomorphometric and radiographic effects of growth guidance with tension-band devices (eight-Plate and FlexTack) in a pig model.Acta orthopaedica · 2021Article
- Growth modulation of angular deformities with a novel constant force implant concept-preclinical results.Journal of children's orthopaedics · 2021Article
- Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review.Frontiers in bioengineering and biotechnology · 2021Review
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5 authors.
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Abstract
purposeHemiepiphysiodesis has been widely used to correct angular deformity of long bone in immature patients. However, there is a limited knowledge about the biomechanical effect of this technique on the histopathological changes of the growth plate and the mechanism of recurrence of malformation after implant removal. We aimed to evaluate the biomechanical effect of hemiepiphysiodesis on the histopathological changes of the growth plate and the mechanism of recurrence of malformation after implant removal in Bama miniature pigs, and to explore the role of asymmetric stress during this procedure.
methodsEight 3-month-old male Bama miniature pigs sustained surgeries on the bilateral medial hind leg proximal tibia as the intervention group (n=16), and four pigs sustained bilateral sham surgeries as the control (n=8). In the 18
resultsH&E staining showed the thickness of growth plate to be varied in different areas. In the IP group, the thickness of growth plate in areas A and B was statistically significantly thinner than that in area C (p<0.05). In the IR group, the thickness of growth plate in areas A and B was statistically significantly thicker than that in area C (p<0.05). TUNEL staining showed that the apoptosis rate increased significantly after hemiepiphysiodesis and declined after implant removal (p<0.05). Immunohistochemical staining suggested that the expression of Caspase-3, Caspase-9, P65, and CHOP protein was upregulated in the experimental group and downregulated after implant removal.
conclusionThe thickness parameter of the growth plate changes with asymmetric pressure. When the pressure is relieved, the recurrence of malformation is related to the thickening of the growth plate.
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