ArticleFrontiers in cardiovascular medicine2018
A Large Animal Model of Right Ventricular Failure due to Chronic Thromboembolic Pulmonary Hypertension: A Focus on Function.
Article in Frontiers in cardiovascular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Minimally Invasive Porcine Model for Chronic Thromboembolic Pulmonary Hypertension.Pulmonary circulation · 2026Article
- Large animal models of right heart failure due to pulmonary hypertension: a bridge to translational success.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Animal models of chronic thromboembolic pulmonary hypertension.Animal models and experimental medicine · 2026Review
- The Unexpected Protective Role of Thrombosis in Lung Injury via Endothelial Alox15.Circulation research · 2026Article
- Bayesian parameter inference and uncertainty quantification for a computational pulmonary hemodynamics model using Gaussian processes.Computers in biology and medicine · 2025Article
- Revisiting Murray's Law in Pulmonary Arteries: Exploring Branching Patterns and Principles.Journal of biomechanical engineering · 2025Article
- A swine model of severe chronic thromboembolic pulmonary hypertension induced by repeated pulmonary artery long suture injection.Frontiers in cardiovascular medicine · 2025Article
- Chronic Thromboembolic Pulmonary Hypertension: the Bench.Current cardiology reports · 2021Review
- Article
- Model of Chronic Thromboembolic Pulmonary Hypertension in Rats Caused by Repeated Intravenous Administration of Partially Biodegradable Sodium Alginate Microspheres.International journal of molecular sciences · 2021Article
- Chronic Thromboembolic Pulmonary Hypertension - What Have We Learned From Large Animal Models.Frontiers in cardiovascular medicine · 2021Review
- Mid-regional pro-atrial natriuretic peptide and copeptin as indicators of disease severity and therapy response in CTEPH.ERJ open research · 2020Article
- Establishment of adult right ventricle failure in ovine using a graded, animal-specific pulmonary artery constriction model.Animal models and experimental medicine · 2020Article
- Pharmacokinetics of single dose sildenafil orally administered in canine models of chronic embolic pulmonary hypertension.The Journal of veterinary medical science · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic thromboembolic pulmonary hypertension (CTEPH) is a debilitating disease that progresses to right ventricular (RV) failure and death if left untreated. Little is known regarding the progression of RV failure in this disease, greatly limiting effective prognoses, and therapeutic interventions. Large animal models enable the use of clinical techniques and technologies to assess progression and diagnose failure, but the existing large animal models of CTEPH have not been shown to replicate the functional consequences of the RV, i.e., RV failure. Here, we created a canine embolization model of CTEPH utilizing only microsphere injections, and we used a combination of right heart catheterization (RHC), echocardiography (echo), and magnetic resonance imaging (MRI) to quantify RV function. Over the course of several months, CTEPH led to a 6-fold increase in pulmonary vascular resistance (PVR) in four adult, male beagles. As evidenced by decreased cardiac index (0.12 ± 0.01 v. 0.07 ± 0.01 [L/(min
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.