Evidence map›Paper›PMID 30687591›Full record

ArticleCurrent epidemiology reports2018

Developmental Origins of Disease: Emerging Prenatal Risk Factors and Future Disease Risk.

Izzuddin M Aris, Abby F Fleisch, Emily Oken

Abstract read
In one paragraph

Article in Current epidemiology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Maternal stressful life events during pregnancy and childhood asthma and wheeze.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
    Article
  7. Review
  8. Article
  9. The importance of nutrition in pregnancy and lactation: lifelong consequences.American journal of obstetrics and gynecology · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Izzuddin M ArisDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
Abby F FleischPediatric Endocrinology and Diabetes, Maine Medical Center, Portland, ME, USA.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Translational Research Core - Health Engagement & Action Translational (HEAT)P30DK092924 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI Alyce Sophia Adams, HILARY Kessler SELIGMAN · 2011 to 2026
$9.2M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUG3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI KLEINMAN, KENNETH P., OKEN, EMILY · 2016 to 2017
$4.1M
The Fetal and Childhood Environment, Oxidative Balance, Inflammation and AsthmaR01AI102960 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLD, DIANE R, OKEN, EMILY · 2013 to 2017
$4.0M
Air Pollution Exposure during Pregnancy, Maternal Glycemia, and OffspringGrowthK23ES024803 · NIEHS · MAINEHEALTH · PI FLEISCH, ABBY · 2015 to 2019
$835k
NIAID NIH HHS R01 AI102960NICHD NIH HHS R01 HD034568NIDDK NIH HHS P30 DK092924NIEHS NIH HHS K23 ES024803NIH HHS UG3 OD023286NIH HHS UH3 OD023286
6 · The paper itself

Abstract

purpose of reviewMany of the diseases and dysfunctions described in the paradigm of the developmental origins of health and disease have been studied in relation to prenatal nutrition or environmental toxicant exposures. Here, we selectively review the current research on four exposures-two nutritional and two environmental-that have recently emerged as prenatal risk factors for long-term health outcomes. RECENT

findingsRecent studies have provided strong evidence that prenatal exposure to (1) excessive intake of sugar-sweetened beverages, (2) unhealthy dietary patterns, (3) perfluoroalkyl substances, and (4) fine particulate matter, may increase risk of adverse health outcomes, such as obesity, cardiometabolic dysfunction, and allergy/asthma. SUMMARY: Emerging prenatal nutritional factors and environmental toxicants influence offspring long-term health. More work is needed to identify the role of paternal exposures and maternal exposures during the preconception period and to further elucidate causality through intervention studies. The ubiquity of these emerging nutritional and environmental exposures makes this area of inquiry of considerable public health importance.

Indexed as

developmental origins of diseasedietary patternsfine particulate matter pollutionperfluoroalkyl substancesprenatal risk factorssugar-sweetened beverages

Identifiers

PMID30687591
PMCPMC6345523

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.