ReviewFrontiers in immunology2018
Immunity to the Dual Threat of Silica Exposure and
Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- AWMF S2k Guideline: Diagnosis and Assessment of Lung Disease Caused by Occupational Silica Dust Exposure (Silicosis) - Disease No. 4101 as per Occupational Diseases Ordinance (BKV) Annex 1.Respiration; international review of thoracic diseases · 2026Guideline
- The association between silica exposure, silicosis and tuberculosis: a systematic review and meta-analysis.BMC public health · 2021Pooled it
- Construction and application of a diagnostic model for tuberculosis in patients with pneumoconiosis.Frontiers in medicine · 2026Article
- Cutting for Stone: A Case Report of Isolated Pleural Silicosis in an Engineered Stone Fabrication Worker.CHEST pulmonary · 2025Article
- Transgression of planetary boundaries and the effects on child health through an infectious diseases lens.Current opinion in pediatrics · 2025Review
- Beyond the Lungs: A Case Report of Disseminated Tuberculosis With Multisystem Involvement.Cureus · 2025Article
- Inhibition of IRF3-STING axis interaction in silicosis using natural compounds: an in-silico study using molecular docking, ADMET, molecular dynamics and MMPBSA approach.In silico pharmacology · 2025Article
- Burden and challenges in managing TB infection among people with occupational exposure to silica in India.IJTLD open · 2024Article
- Silicotuberculosis: a critical narrative review.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Multi-omics and multi-stages integration identified a novel variant associated with silicosis risk.Archives of toxicology · 2024Article
- Prevalence of pulmonary tuberculosis among casual labourers working in selected road construction sites in central Uganda.PloS one · 2024Article
- Silico-tuberculosis amidst COVID-19 pandemic: global scenario and Indian perspective.Annals of medicine and surgery (2012) · 2023Review
- A Complex Case of Pulmonary Silico-Tuberculosis and Review of Literature.Diagnostics (Basel, Switzerland) · 2023Article
- Silicosis, tuberculosis and silica exposure among artisanal and small-scale miners: A systematic review and modelling paper.PLOS global public health · 2023Article
- Enterosorbents in complex therapy of food allergies: a focus on digestive disorders and systemic toxicity in children.Frontiers in immunology · 2023Review
- Article
- Understanding the pathogenesis of occupational coal and silica dust-associated lung disease.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Differential immunological effects of silica nanoparticles on peripheral blood mononuclear cells of silicosis patients and controls.Frontiers in immunology · 2022Article
- Mini-review: Silico-tuberculosis.Journal of clinical tuberculosis and other mycobacterial diseases · 2021Review
- Mycobactericidal Effects of Different Regimens Measured by Molecular Bacterial Load Assay among People Treated for Multidrug-Resistant Tuberculosis in Tanzania.Journal of clinical microbiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to silica and the consequent development of silicosis are well-known health problems in countries with mining and other dust producing industries. Apart from its direct fibrotic effect on lung tissue, chronic and immunomodulatory character of silica causes susceptibility to tuberculosis (TB) leading to a significantly higher TB incidence in silica-exposed populations. The presence of silica particles in the lung and silicosis may facilitate initiation of tuberculous infection and progression to active TB, and exacerbate the course and outcome of TB, including prognosis and survival. However, the exact mechanisms of the involvement of silica in the pathological processes during mycobacterial infection are not yet fully understood. In this review, we focus on the host's immunological response to both silica and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.