ReviewFrontiers in microbiology2018
Two-Component Signal Transduction Systems: A Major Strategy for Connecting Input Stimuli to Biofilm Formation.
Review in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 111 citations in OpenAlex.
- Proteomic Evidence for Biofilm-Mediated Copper Stress Adaptation in Oleidesulfovibrio alaskensis G20.Environmental microbiology · 2026Article
- Role of the PhoP/PhoQ Two-Component Regulatory System in Biofilm Formation in Acid-AdaptedFoods (Basel, Switzerland) · 2025Article
- Integrated genomic and mutagenesis analysis of Pseudomonas argentinensis SA190 reveals mechanisms of plant root colonization and stress resilience.BMC microbiology · 2025Article
- Enrichment of vitamin BMicrobiome · 2025Article
- Article
- Long-read methylome analysis of Oleidesulfovibrio alaskensis G20 biofilm under copper stress.Scientific reports · 2025Article
- A nitric oxide-sensing two-component system regulates a range of infection-related phenotypes inmSphere · 2025Article
- Alleviation of mycobacterial infection by impairing motility and biofilm formation via natural and synthetic molecules.World journal of microbiology & biotechnology · 2025Review
- Combined Analysis of Transcriptomes and Metabolomes Reveals Key Genes and Substances That Affect the Formation of a Multi-Species Biofilm by Nine Gut Bacteria.Microorganisms · 2025Article
- Current models in bacterial hemicellulase-encoding gene regulation.Applied microbiology and biotechnology · 2024Review
- Role of the SaeRS Two-Component Regulatory System in Group BMicroorganisms · 2024Article
- Combinatorial control ofmSystems · 2024Article
- Crosstalk involving two-component systems inJournal of bacteriology · 2024Review
- Review
- Bacteria employ lysine acetylation of transcriptional regulators to adapt gene expression to cellular metabolism.Nature communications · 2024Article
- Prognostic Value of Gut Microbiome for Conversion from Mild Cognitive Impairment to Alzheimer's Disease Dementia within 4 Years: Results from the AlzBiom Study.International journal of molecular sciences · 2024Article
- In silico identification of drug targets and vaccine candidates against Bartonella quintana: a subtractive proteomics approach.Memorias do Instituto Oswaldo Cruz · 2024Article
- Insights into Kinases of ESKAPE Pathogens for Therapeutic Interventions.Cardiovascular & hematological agents in medicinal chemistry · 2024Review
- Development and Regulation of the Extreme Biofilm Formation ofInternational journal of molecular sciences · 2023Article
- Biofilm formation: mechanistic insights and therapeutic targets.Molecular biomedicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biofilms are multicellular communities of microbes that are encased within an extracellular matrix. Environmental factors induce bacteria to form biofilm. Bacteria have several regulatory mechanisms in response to environmental changes, and the two-component signal transduction system (TCS) is a major strategy in connecting changes in input signals to changes in cellular physiological output. The TCS employs multiple mechanisms such as cross-regulation, to integrate and coordinate various input stimuli to control biofilm formation. In this mini-review, we demonstrate the roles of TCS on biofilm formation, illustrating these input signals and modulation modes, which may be utilized by future investigations in elucidating the regulatory signals and underlying the mechanisms of biofilm formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.