ArticleFrontiers in human neuroscience2018
Neural Substrates of Cognitive Motor Interference During Walking; Peripheral and Central Mechanisms.
Article in Frontiers in human neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Relationship between motor performance and cortical activity of older neurological disorder patients with dyskinesia using fNIRS: A systematic review.Frontiers in physiology · 2023Pooled it
- Brain activity during dual task gait and balance in aging and age-related neurodegenerative conditions: A systematic review.Experimental gerontology · 2019Pooled it
- Effects of unilateral lower limb exoskeleton robot on gait improvement and brain function in patients with chronic stroke: a randomized clinical trial.Journal of neuroengineering and rehabilitation · 2025Trial
- Transcutaneous auricular vagus nerve stimulation improves gait and cortical activity in Parkinson's disease: A pilot randomized study.CNS neuroscience & therapeutics · 2023Trial
- Aging in motion: how age and age simulation shape dual-task walking and memory.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- Effects of repetitive transcranial magnetic stimulation on motor ability, neurophysiological changes, mental health, and activities of daily living in spinal cord injury: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Cortical activation, gait performance, and muscle activation during dual-task walking in older adults with mild cognitive impairment.BMC geriatrics · 2026Article
- The gait performance, sensorimotor cortical activation and their correlation during walking task among children with cerebral palsy: a fNIRS study.BMC pediatrics · 2026Article
- How aging impacts cortical dynamics and gait during dual-task turning revealed by fNIRS.GeroScience · 2026Article
- Distinct neural mechanisms underlying the effects of agility and resistance-aerobic training on executive function and gait in young adults.Frontiers in psychology · 2026Article
- The association between amyloid-beta deposition on dual-task gait performance is partially moderated by cognitive functions in healthy older adults.Scientific reports · 2025Article
- Probing gait adaptations: The impact of aging on dynamic stability and reflex control mechanisms under varied weight-bearing conditions.European journal of applied physiology · 2025Article
- Differences Between Patients With Multiple System Atrophy With Predominant Parkinsonism and Parkinson's Disease Based on fNIRS and Gait Analysis.CNS neuroscience & therapeutics · 2025Article
- Frontiers in neuro-rehabilitation: neural basis of cognitive contributions to movement across neurological populations.Frontiers in neurology · 2025Review
- The impact of interactive motor-cognitive dual tasking on brain activation, functional connectivity, and behavioral performance in healthy adults: an fNIRS study.Frontiers in human neuroscience · 2025Article
- The Effect of Cognitive-Motor Dual Tasks on the Risk of Falls in Female Saudi Students: A Cross-Sectional Study.Risk management and healthcare policy · 2025Article
- Frontal and parietal cortices activation during walking is repeatable in older adults based on fNIRS.Heliyon · 2024Article
- Adaptive gait responses to varying weight-bearing conditions: Inferences from gait dynamics and H-reflex magnitude.Experimental physiology · 2024Article
- Role of exercise in modulating prefrontal cortical activation for improved gait and cognition in Parkinson's disease patients.Physical activity and nutrition · 2024Article
- Cognitive Function and Postural Control Strategies in Relation to Disease Progression in Patients with Parkinson's Disease.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current gait control models suggest that independent locomotion depends on central and peripheral mechanisms. However, less information is available on the integration of these mechanisms for adaptive walking. In this cross-sectional study, we investigated gait control mechanisms in people with Parkinson's disease (PD) and healthy older (HO) adults: at self-selected walking speed (SSWS) and at fast walking speed (FWS). We measured effect of additional cognitive task (DT) and increased speed on prefrontal (PFC) and motor cortex (M1) activation, and Soleus H-reflex gain. Under DT-conditions we observed increased activation in PFC and M1. Whilst H-reflex gain decreased with additional cognitive load for both groups and speeds, H-reflex gain was lower in PD compared to HO while walking under ST condition at SSWS. Attentional load in PFC excites M1, which in turn increases inhibition on H-reflex activity during walking and reduces activity and sensitivity of peripheral reflex during the stance phase of gait. Importantly this effect on sensitivity was greater in HO. We have previously observed that the PFC copes with increased attentional load in young adults with no impact on peripheral reflexes and we suggest that gait instability in PD may in part be due to altered sensorimotor functioning reducing the sensitivity of peripheral reflexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.