Evidence map›Paper›PMID 30687034›Full record

ArticleFrontiers in behavioral neuroscience2018

Gene-Environment Interaction in a Conditional NMDAR-Knockout Model of Schizophrenia.

Alexei M Bygrave, Simonas Masiulis, Dimitri M Kullmann, David M Bannerman, Dennis Kätzel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Alexei M BygraveDepartment of Experimental Psychology, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
Simonas MasiulisDepartment of Experimental Psychology, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
Dimitri M KullmannInstitute of Neurology, University College London, London, United Kingdom.
David M BannermanDepartment of Experimental Psychology, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
Dennis KätzelDepartment of Experimental Psychology, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
University of Oxford · GBUniversity College London · GB

Funding

Medical Research Council G116/147Medical Research Council MR/L01095X/1Wellcome Trust 212285/Z/18/Z
6 · The paper itself

Abstract

Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in the positive, negative or cognitive symptom domains of schizophrenia in a mouse line modeling NMDA-receptor (NMDAR) hypofunction in forebrain inhibitory interneurons (

Indexed as

gene-environment interactioninterneuronsNMDAR-receptor hypofunctionrisk factorsschizophrenia

Identifiers

PMID30687034
PMCPMC6338026
OpenAlexW2909540571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.