Evidence map›Paper›PMID 30686969›Full record

ReviewFrontiers in neuroscience2018

Tracking Neural Progenitor Cell Migration in the Rodent Brain Using Magnetic Resonance Imaging.

Christiane L Mallett, Dorela D Shuboni-Mulligan, Erik M Shapiro

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christiane L MallettMolecular and Cellular Imaging Laboratory, Department of Radiology, Michigan State University, East Lansing, MI, United States.
Dorela D Shuboni-MulliganMolecular and Cellular Imaging Laboratory, Department of Radiology, Michigan State University, East Lansing, MI, United States.
Erik M ShapiroMolecular and Cellular Imaging Laboratory, Department of Radiology, Michigan State University, East Lansing, MI, United States.
Michigan State University · US

Funding

Quantitative molecular and cellular MRI of hepatocyte transplantationR01DK107697 · NIDDK · MICHIGAN STATE UNIVERSITY · PI SHAPIRO, ERIK · 2015 to 2018
$2.1M
Molecular Imaging for Detection of Synthetic Biology Circuits, Oscillators and Toggle Switches in Regenerative MedicineR01NS104306 · NINDS · MICHIGAN STATE UNIVERSITY · PI GILAD, ASSAF A · 2018 to 2021
$1.3M
MRI-based immune cell tracking in Alzheimer?s diseaseR21AG041266 · NIA · YALE UNIVERSITY · PI SHAPIRO, ERIK · 2011 to 2012
$435k
MRI Contrast Agents for In vivo Monitoring of Stem Cell DifferentiationR21EB017881 · NIBIB · MICHIGAN STATE UNIVERSITY · PI SHAPIRO, ERIK · 2014 to 2015
$433k
(PQC5) MRI of magnetically labeled immune/stem cells for early tumor detectionR21CA185163 · NCI · MICHIGAN STATE UNIVERSITY · PI SHAPIRO, ERIK · 2014 to 2015
$380k
NCI NIH HHS R21 CA185163NIA NIH HHS R21 AG041266NIBIB NIH HHS R21 EB017881NIDDK NIH HHS R01 DK107697NINDS NIH HHS R01 NS104306
6 · The paper itself

Abstract

The study of neurogenesis and neural progenitor cells (NPCs) is important across the biomedical spectrum, from learning about normal brain development and studying disease to engineering new strategies in regenerative medicine. In adult mammals, NPCs proliferate in two main areas of the brain, the subventricular zone (SVZ) and the subgranular zone, and continue to migrate even after neurogenesis has ceased within the rest of the brain. In healthy animals, NPCs migrate along the rostral migratory stream (RMS) from the SVZ to the olfactory bulb, and in diseased animals, NPCs migrate toward lesions such as stroke and tumors. Here we review how MRI-based cell tracking using iron oxide particles can be used to monitor and quantify NPC migration in the intact rodent brain, in a serial and relatively non-invasive fashion. NPCs can either be labeled directly

Indexed as

cell transplantationguinea pigsmiceMRI – magnetic resonance imagingneural progenitor and stem cellsneurogenesisrodents (ratsvoles)

Identifiers

PMID30686969
PMCPMC6337062
OpenAlexW2910941309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.