Evidence map›Paper›PMID 30686949›Full record

ArticleJournal of Korean medical science2019

Correlation between Morphologic Grading and Euploidy Rates of Blastocysts, and Clinical Outcomes in In Vitro Fertilization Preimplantation Genetic Screening.

Min Kyoung Kim, Jae Kyun Park, Yunmi Jeon, Seung-Ah Choe, Hee Jun Lee, Jayeon Kim, Eun Mi Chang, Ji Won Kim, Sang Woo Lyu, Jin Young Kim and 3 more

Abstract read
In one paragraph

Article in Journal of Korean medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  15. Timing day-3 vitrification for PGT-M embryos: pre- or post-blastomere biopsy?Journal of assisted reproduction and genetics · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Min Kyoung KimDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-1753-2674
Jae Kyun ParkDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-5333-4990
Yunmi JeonDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-2751-8718
Seung-Ah ChoeCHA Fertility Center, Seoul Station, Seoul, Korea.ORCID https://orcid.org/0000-0001-6270-5020
Hee Jun LeeDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2652-9864
Jayeon KimCHA Fertility Center, Seoul Station, Seoul, Korea.ORCID https://orcid.org/0000-0001-7167-2304
Eun Mi ChangDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-9256-5057
Ji Won KimDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5066-1593
Sang Woo LyuDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5572-0898
Jin Young KimDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5156-0751
In Pyung KwakDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-0812-6260
Woo Sik LeeDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2329-1774
Tae Ki YoonCHA Fertility Center, Seoul Station, Seoul, Korea.ORCID https://orcid.org/0000-0001-6314-451X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe standard morphological evaluation has been widely used for embryo selection, but it has limitations. This study aimed to investigate the correlation between morphologic grading and euploidy rate of in vitro fertilization (IVF) preimplantation genetic screening (PGS) and compare the pregnancy rates in young and old ages.

methodsThis is a retrospective study using the medical records of patients who underwent IVF procedures with PGS between January 2016 and February 2017 in a single center. The embryo grades were categorized into 4 groups: excellent, good, fair, and poor. Basic characteristics, euploidy rates, clinical pregnancy (CP) rates and ongoing pregnancy rates were analyzed.

resultsThe excellent group had significantly higher rate of euploid embryos than fair group (47.82% vs. 29.33%;

conclusionThe significant differences among the euploidy rates of different morphologic embryo grades demonstrated the positive correlations between the morphologic grading of the embryo and the euploidy rate of PGS. Additionally, there was no significant difference between the younger and older patients' CP rates. These findings emphasize the fact that old age patients might benefit from PGS whatever the indication of PGS is.

Indexed as

Genetic TestingPreimplantation DiagnosisAdultBlastocystChromosomes, HumanEmbryo, MammalianEmbryo TransferFemaleFertilization in VitroHumansLogistic ModelsMaleMaternal AgePregnancyPregnancy RateRetrospective StudiesEuploidy RateMorphologic GradingPGSPregnancy Rate

Identifiers

PMID30686949
PMCPMC6345636

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.