ArticleIEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society
Enhanced Detection of Single Viruses On-Chip via Hydrodynamic Focusing.
Article in IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Nano/microfluidic device for high-throughput passive trapping of nanoparticles.Biomicrofluidics · 2023Article
- Comparison of Illumination Methods for Flow-Through Optofluidic Biosensors.Micromachines · 2023Article
- Microfluidics-Based POCT for SARS-CoV-2 Diagnostics.Micromachines · 2022Review
- The Rise of the OM-LoC: Opto-Microfluidic Enabled Lab-on-Chip.Micromachines · 2021Review
- Article
- Ultrasensitive detection of SARS-CoV-2 RNA and antigen using single-molecule optofluidic chip.APL photonics · 2021Article
- Optofluidic Flow-Through Biosensor Sensitivity - Model and Experiment.Journal of lightwave technology : a joint IEEE/OSA publication · 2021Article
- Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaks.Proceedings. Mathematical, physical, and engineering sciences · 2020Review
- 3D Hydrodynamic Focusing in Microscale Optofluidic Channels Formed with a Single Sacrificial Layer.Micromachines · 2020Article
- 3D hydrodynamic focusing in microscale channels formed with two photoresist layers.Microfluidics and nanofluidics · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Planar optofluidics provide a powerful tool for facilitating chip-scale light-matter interactions. Silicon-based liquid core waveguides have been shown to offer single molecule sensitivity for efficient detection of bioparticles. Recently, a PDMS based planar optofluidic platform was introduced that opens the way to rapid development and prototyping of unique structures, taking advantage of the positive attributes of silicon dioxide-based optofluidics and PDMS based microfluidics. Here, hydrodynamic focusing is integrated into a PDMS based optofluidic chip to enhance the detection of single H1N1 viruses on-chip. Chip-plane focusing is provided by a system of microfluidic channels to force the particles towards a region of high optical collection efficiency. Focusing is demonstrated and enhanced detection is quantified using fluorescent polystyrene beads where the coefficient of variation is found to decrease by a factor of 4 with the addition of hydrodynamic focusing. The mean signal amplitude of fluorescently tagged single H1N1 viruses is found to increase with the addition of focusing by a factor of 1.64.
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Registered trials
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