ArticleWorld journal of gastroenterology2019
Effects of positive acceleration (+Gz stress) on liver enzymes, energy metabolism, and liver histology in rats.
Article in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Alterations in the hepatic drug-metabolizing enzyme network of mice induced by +Gz exposure and its impact on the pharmacokinetics and pharmacodynamics of modafinil.Frontiers in pharmacology · 2026Article
- Relationship between sleep quality and gravitational Tolerance.Sleep & breathing = Schlaf & Atmung · 2024Article
- Metabolic flexibility associated with flight time among combat pilots of the Brazilian air force.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Response of plantain (Plantago lanceolata L.) supplementation on nutritional, endo-parasitic, and endocrine status in lambs.Tropical animal health and production · 2021Article
- Calculus Cholecystitis Complicated with Variations of Extrahepatic Bile Duct: Clinical Experience and Aeromedical Analysis of 3 Cases in Aviation Pilots.Case reports in gastroenterologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to high sustained +Gz (head-to-foot inertial load) is known to have harmful effects on pilots' body in flight. Although clinical data have shown that liver dysfunction occurs in pilots, the precise cause has not been well defined.
aimTo investigate rat liver function changes in response to repeated +Gz exposure.
methodsNinety male Wistar rats were randomly divided into a blank control group (BC group,
resultsAfter repeated +Gz exposures in the 6GS and the 10GS groups, the velocity and flow signal in the portal vein (PV) were significantly decreased as compared to the BC group at 0 h after exposure. Meanwhile, we found that the PV diameter did not change significantly. However, rats in the 6GS group had a much higher portal venous flow volume than the 10GS group at 0 h after exposure. The 6GS group had significantly lower ALT, AST, and MDA values than the 10GS group 0 h and 6 h post exposure. The Na
conclusionRepeated +Gz exposures transiently cause hepatocyte injury and affect liver metabolism and morphological structure.
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Registered trials
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