Evidence map›Paper›PMID 30686732›Full record

ArticleNeuron2019

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain.

Dustin P Green, Nathachit Limjunyawong, Naina Gour, Priyanka Pundir, Xinzhong Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 244 papers.

0numbers the graph read from it
0cells of the map it votes in
244citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

244 citing papers in PubMed.

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184 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Dustin P GreenThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Nathachit LimjunyawongThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Naina GourThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Priyanka PundirThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Xinzhong DongThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD, USA. Electronic address: xdong2@jhmi.edu.

Funding

Functional analysis of the Mrg receptor family in pain sensationR01NS054791 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DONG, XINZHONG · 2007 to 2020
$5.0M
Interdisciplinary Training in Biobehavioral Pain ResearchT32NS070201 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DONG, XINZHONG, SMITH, MICHAEL T · 2010 to 2024
$3.6M
Characterization of a dendritic cell specific receptor critical for SJSR01AI135186 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DONG, XINZHONG · 2018 to 2021
$1.6M
The Role of the Mast Cells in Postoperative PainF32GM121030 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, DUSTIN PEPPER · 2016 to 2017
$111k
NIAID NIH HHS R01 AI135186NIGMS NIH HHS F32 GM121030NINDS NIH HHS R01 NS054791NINDS NIH HHS T32 NS070201
6 · The paper itself

Abstract

Mast cells can be found in close proximity to peripheral nerve endings where, upon activation, they release a broad range of pro-inflammatory cytokines and chemokines. However, the precise mechanism underlying this so-called neurogenic inflammation and associated pain has remained elusive. Here we report that the mast-cell-specific receptor Mrgprb2 mediates inflammatory mechanical and thermal hyperalgesia and is required for recruitment of innate immune cells at the injury site. We also found that the neuropeptide substance P (SP), an endogenous agonist of Mrgprb2, facilitates immune cells' migration via Mrgprb2. Furthermore, SP activation of the human mast cell led to the release of multiple pro-inflammatory cytokines and chemokines via the human homolog MRGPRX2. Surprisingly, the SP-mediated inflammatory responses were independent of its canonical receptor, neurokinin-1 receptor (NK-1R). These results identify Mrgprb2/X2 as an important neuroimmune modulator and a potential target for treating inflammatory pain.

Indexed as

AnimalsCell LineCytokinesFemaleHumansMaleMast CellsMiceMice, Inbred C57BLNeuralgiaReceptors, G-Protein-CoupledReceptors, Neurokinin-1Substance PCytokinesMrgprb2 protein, mouseMrgprx2 protein, mouseReceptors, G-Protein-CoupledReceptors, Neurokinin-1Substance P

Identifiers

PMID30686732
PMCPMC6462816

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.