ArticleEnvironmental science and pollution research international2019
Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits.
Article in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Impacts of propolis and Spirulina platensis supplementation on growth, nutrient digestibility, and gut microbiota of Japanese quails under heat stress.Scientific reports · 2025Article
- Role of Nannochloropsis Oculata supplement in improving performance, antioxidant status, blood metabolites, and egg quality of laying hens under hot environmental conditions.Scientific reports · 2024Article
- Effects ofVeterinary sciences · 2023Article
- Changes in Spirulina's Physical and Chemical Properties during Submerged and Solid-State Lacto-Fermentation.Toxins · 2023Article
- Potential ameliorative role of Spirulina platensis in powdered or extract forms against cyclic heat stress in broiler chickens.Environmental science and pollution research international · 2022Article
- Spirulina platensis protects against microcystin-LR-induced toxicity in rats.Environmental science and pollution research international · 2022Article
- Article
- Therapeutic effects of chitosan-embedded vitamin C, E nanoparticles against cisplatin-induced gametogenic and androgenic toxicity in adult male rats.Environmental science and pollution research international · 2021Article
- The nephroprotective properties of taurine-amikacin treatment in rats are mediated through HSP25 and TLR-4 regulation.The Journal of antibiotics · 2021Article
- Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis with regard to androgen receptor expression in rats.Environmental science and pollution research international · 2021Article
- Elucidating the Multi-Targeted Role of Nutraceuticals: A Complementary Therapy to Starve Neurodegenerative Diseases.International journal of molecular sciences · 2021Review
- Effects of Spirulina platensis and Amphora coffeaeformis as dietary supplements on blood biochemical parameters, intestinal microbial population, and productive performance in broiler chickens.Environmental science and pollution research international · 2021Article
- Protective effects of Citrus limonia oil against cisplatin-induced nephrotoxicity.Environmental science and pollution research international · 2020Article
- Exogenous ascorbic acid induces systemic heat stress tolerance in tomato seedlings: transcriptional regulation mechanism.Environmental science and pollution research international · 2020Article
- The potential role of nano-selenium and vitamin C on the performances of Nile tilapia (Oreochromis niloticus).Environmental science and pollution research international · 2020Article
- Selenium-Containing Protein From Selenium-EnrichedFrontiers in physiology · 2020Article
- The nephroprotective effects of allicin and ascorbic acid against cisplatin-induced toxicity in rats.Environmental science and pollution research international · 2019Article
- Estimation of cadmium content in Egyptian foodstuffs: health risk assessment, biological responses of human HepG2 cells to food-relevant concentrations of cadmium, and protection trials using rosmarinic and ascorbic acids.Environmental science and pollution research international · 2019Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current study was performed to investigate the nephroprotective efficacy of Spirulina platensis (SP) and the possible benefits of combining SP and ascorbic acid (AA) in protecting against amikacin (AMK)-induced nephrotoxicity in rabbits. Forty-two male New Zealand rabbits were allocated to seven equal groups, receiving (I) normal saline as negative controls, (II) oral SP (500 mg/kg body weight), (III) oral AA (20 mg/kg bw), (IV) intramuscular AMK injection (100 mg/kg bw), (V) AMK plus SP, (VI) AMK plus AA, or (VII) AMK plus SP and AA at the aforementioned doses. The treatments were given once/day for 7 days. Data analysis showed that in comparison to the control group, AMK-intoxicated rabbits showed significant increases (p ≤ 0.05) in serum concentrations of creatinine, uric acid, and urea, as well as renal tissue concentrations of tumor necrosis factor-α [TNF-α], malondialdehyde [MDA], and nitric oxide [NO]. Moreover, significant (p ≤ 0.05) reductions in renal glutathione concentration, antioxidant enzymatic activities (catalase, glutathione peroxidase, and superoxide dismutase), and total antioxidant capacity were noted following AMK intoxication. Treatment by SP ameliorated most of the aforementioned AMK-induced alterations. Although treatment with AA significantly reduced the renal tissue MDA, NO, and TNF-α concentrations, it was not associated with significant ameliorations of AMK-induced changes in the serum concentrations of renal function markers or renal tissue antioxidant parameters. The nephroprotective effects of SP-AA combination were more potent than SP alone in several parameters. In conclusion, SP alone or in combination with AA minimized the nephrotoxic effects of AMK through their antioxidant and anti-inflammatory activities.
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