ArticleSleep & breathing = Schlaf & Atmung2019
Short-term effects of continuous positive airway pressure on oxidative stress in severe sleep apnea.
Article in Sleep & breathing = Schlaf & Atmung, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Oxidative stress and inflammatory profiles in obstructive sleep apnea: are short-term CPAP or aerobic exercise therapies effective?Sleep & breathing = Schlaf & Atmung · 2020Trial
- iNOS/NOX-mediated stress, telomerase activity, and hTERT expression as potential biomarkers in sleep apnea.Irish journal of medical science · 2026Article
- Influence of Obstructive Sleep Apnea on Oxidative Stress in Pregnancy.International journal of molecular sciences · 2025Article
- P66Shc is increased in peripheral blood mononuclear cells of the patients with obstructive sleep apnea.International journal of medical sciences · 2023Article
- The critical issue linking lipids and inflammation: Clinical utility of stopping oxidative stress.Frontiers in cardiovascular medicine · 2022Review
- Oxidative Stress: A Putative Link Between Lower Urinary Tract Symptoms and Aging and Major Chronic Diseases.Frontiers in medicine · 2022Review
- A narrative review of exploring potential salivary biomarkers in respiratory diseases: still on its way.Journal of thoracic disease · 2021Review
- Oxidative Stress and Inflammation Biomarker Expression in Obstructive Sleep Apnea Patients.Journal of clinical medicine · 2021Review
- Oxidative Stress Markers among Obstructive Sleep Apnea Patients.Oxidative medicine and cellular longevity · 2021Review
- Serum high-mobility group box 1 protein level correlates with the lowest SaOBrazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeObstructive sleep apnea (OSA) is associated with oxidative stress that is involved in the pathogenesis of cardiovascular and metabolic complications. The concentrations of salivary markers of oxidative stress in patients with OSA increase considerably during the night. The dynamics is not affected by continuous positive airway pressure (CPAP) in mild to moderate OSA. The aim of this study was to analyze the short-term effects of CPAP on salivary oxidative stress markers in patients with severe OSA.
methodsSalivary samples were collected from 24 patients with apnea-hypopnea index higher than 30 during the first (diagnostic) night, who were treated by CPAP during the second (therapeutic) night.
resultsThe salivary markers of oxidative stress (TBARS, AGEs, and AOPP) were higher in the morning after the diagnostic night when compared to the evening concentrations (p < 0.01 for TBARS and p < 0.05 for AGEs and AOPP). Treatment by CPAP significantly decreased the morning concentrations of TBARS, AOPP (p < 0.01 for both), and AGEs (p < 0.05). Also, TBARS and AGEs positively correlated with apnea-hypopnea index (r = 0.48 and 0.49, respectively; p < 0.05). Antioxidant statuss was not affected.
conclusionSevere OSA is associated with increased levels of saliva markers for lipid peroxidation, protein oxidative damage, and carbonyl damage. Even short-term CPAP partially prevents oxidative and carbonyl stress during the night and this can be monitored non-invasively using saliva.
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Registered trials
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