Evidence map›Paper›PMID 30685636›Full record

ArticleComprehensive psychiatry2019

Eating disorder recovery is associated with absence of major depressive disorder and substance use disorders at 22-year longitudinal follow-up.

Ani C Keshishian, Nassim Tabri, Kendra R Becker, Debra L Franko, David B Herzog, Jennifer J Thomas, Kamryn T Eddy

Open access · goldAbstract read
In one paragraph

Article in Comprehensive psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Defining Recovery and Relapse in Bulimia Nervosa: A Systematic Review of the Literature.European eating disorders review : the journal of the Eating Disorders Association · 2026
    Pooled it
  2. Recovery From Anorexia Nervosa: A Concept Analysis.Journal of advanced nursing · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ani C KeshishianEating Disorders Clinical and Research Program, Massachusetts General Hospital, USA. Electronic address: akeshishian@mgh.harvard.edu.
Nassim TabriDepartment of Psychology, Carleton University, Ottawa, ON, Canada.
Kendra R BeckerEating Disorders Clinical and Research Program, Massachusetts General Hospital, USA; Department of Psychiatry, Harvard Medical School, USA.
Debra L FrankoEating Disorders Clinical and Research Program, Massachusetts General Hospital, USA; Northeastern University, Boston, MA, USA.
David B HerzogDepartment of Psychiatry, Harvard Medical School, USA.
Jennifer J ThomasEating Disorders Clinical and Research Program, Massachusetts General Hospital, USA; Department of Psychiatry, Harvard Medical School, USA.
Kamryn T EddyEating Disorders Clinical and Research Program, Massachusetts General Hospital, USA; Department of Psychiatry, Harvard Medical School, USA.
Harvard University · USMassachusetts General Hospital · USCarleton University · CA

Funding

Reward Processing in Anorexia Nervosa and Avoidant/Restrictive Food Intake Disorder: Behavior, Hormonal Concentrations, and Brain Activation in Low-Weight Eating Disorders.F32MH111127 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BECKER, KENDRA R · 2016 to 2018
$185k
Defining Recovery for Anorexia and Bulimia Nervosa: A 25-Year Outcome StudyR03MH094832 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDDY, KAMRYN T · 2011 to 2012
$177k
LONGITUDINAL STUDY OF ANOREXIA NERVOSA BULIMIC DISEASER01MH038333 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI HERZOG, DAVID B · 1987 to 1999
–
NIMH NIH HHS F32 MH111127NIMH NIH HHS R01 MH038333NIMH NIH HHS R03 MH094832
6 · The paper itself

Abstract

backgroundPsychiatric comorbidity is common in eating disorders (EDs) and associated with poor outcomes, including increased risk for relapse and premature death. Yet little is known about comorbidity following ED recovery.

methodsWe examined two common comorbidities, major depressive disorder (MDD) and substance use disorder (SUD), in adult women with intake diagnoses of anorexia nervosa and bulimia nervosa who participated in a 22-year longitudinal study. One hundred and seventy-six of 228 surviving participants (77.2%) were interviewed 22 years after study entry using the Eating Disorders Longitudinal Interval Follow-up Evaluation to assess ED recovery status. Sixty-four percent (n = 113) were recovered from their ED. The Structured Clinical Interview for DSM-IV was used to assess MDD and SUD at 22 years.

resultsAt 22-year follow-up, 28% (n = 49) met criteria for MDD, and 6% (n = 11) met criteria for SUD. Those who recovered from their ED were 2.17 times more likely not to have MDD at 22-year follow-up (95% CI [1.10, 4.26], p = .023) and 5.33 times more likely not to have a SUD at 22-year follow-up than those who had not recovered from their ED (95% CI [1.36, 20.90], p = .008).

conclusionCompared to those who had not fully recovered from their ED, those who had recovered were twice as likely not to be diagnosed with MDD in the past year and five times as likely not to be diagnosed with SUDs in the past year. These findings provide evidence that long-term recovery from EDs is associated with recovery from or absence of these common major comorbidities. Because comorbidity in EDs can predict poor outcomes, including greater risk for relapse and premature death, our findings of reduced risk for psychiatric comorbidity following recovery at long-term follow-up is cause for optimism.

Indexed as

AdultDiagnostic and Statistical Manual of Mental DisordersFeeding and Eating DisordersFemaleFollow-Up StudiesHumansLongitudinal StudiesMajor Depressive DisorderMaleMiddle AgedProspective StudiesRecovery of FunctionSubstance-Related DisordersTime FactorsYoung AdultEating disordersMajor depressive disorderRecoverySubstance use disorder

Identifiers

PMID30685636
PMCPMC6420843
OpenAlexW2908813694

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.