ArticlePhotodiagnosis and photodynamic therapy2019
Modeling PpIX effective light fluence at depths into the skin for PDT dose comparison.
Article in Photodiagnosis and photodynamic therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- 3D photogrammetry quantifies the size of basal cell carcinoma lesions with submillimeter accuracy: high correlation with lesion response to photodynamic therapy.Journal of biomedical optics · 2025Trial
- Microneedles meet photomedicine: emerging strategies for diagnosis and therapy of skin diseases.Nanoscale advances · 2026Review
- Observational pilot study of multi-wavelength wearable light dosimetry for erythropoietic protoporphyria.International journal of dermatology · 2024Observational
- Devices and Methods for Dosimetry of Personalized Photodynamic Therapy of Tumors: A Review on Recent Trends.Cancers · 2024Review
- Smartphone-based dual radiometric fluorescence and white-light imager for quantification of protoporphyrin IX in skin.Journal of biomedical optics · 2023Article
- Equivalent efficacy of indoor daylight and lamp-based 5-aminolevulinic acid photodynamic therapy for treatment of actinic keratosis.Skin health and disease · 2023Article
- Color-resolved Cherenkov imaging allows for differential signal detection in blood and melanin content.Journal of biomedical optics · 2023Article
- Daylight-PDT: everything under the sun.Biochemical Society transactions · 2022Review
- Visible light. Part I: Properties and cutaneous effects of visible light.Journal of the American Academy of Dermatology · 2021Review
- Theoretical lateral and axial sensitivity limits and choices of molecular reporters for Cherenkov-excited luminescence in tissue during x-ray beam scanning.Journal of biomedical optics · 2020Article
- Weather-informed Light-tissue Model-Based Dose Planning for Indoor Daylight Photodynamic Therapy.Photochemistry and photobiology · 2020Article
- Reactive oxygen species explicit dosimetry to predict tumor growth for benzoporphyrin derivative-mediated vascular photodynamic therapy.Journal of biomedical optics · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDaylight-activated PDT has seen increased support in recent years as a treatment method for actinic keratosis and other non-melanoma skin cancers. The inherent variability observed in broad-spectrum light used in this methodology makes it difficult to plan and monitor light dose, or compare to lamp light doses.
methodsThe present study expands on the commonly used PpIX-weighted effective surface irradiance metric by introducing a Monte Carlo method for estimating effective fluence rates into depths of the skin. The fluence rates are compared between multiple broadband and narrowband sources that have been reported in previous studies, and an effective total fluence for various treatment times is reported. A dynamic estimate of PpIX concentration produced during pro-drug incubation and treatment is used with the fluence estimates to calculate a photodynamic dose.
resultsEven when there is up to a 5x reduction between the effective surface irradiance of the broadband light sources, the effective fluence below 250 μm depth is predicted to be relatively equivalent. An effective threshold fluence value (0. 70J
conclusionsThe threshold was used to generate lookup tables to prescribe minimal treatment times to achieve depth-dependent cytotoxic effect based on incubation times and irradiance values for each light source.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.