Evidence map›Paper›PMID 30685480›Full record

ArticleToxicology and applied pharmacology2019

Application of hepatic cytochrome b

Lindsay Reed, Radek Indra, Iveta Mrizova, Michaela Moserova, Heinz H Schmeiser, C Roland Wolf, Colin J Henderson, Marie Stiborova, David H Phillips, Volker M Arlt

Open access · hybridAbstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Lindsay ReedDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, London, United Kingdom.
Radek IndraDepartment of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.
Iveta MrizovaDepartment of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.
Michaela MoserovaDepartment of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.
Heinz H SchmeiserDivision of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany.
C Roland WolfDivision of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, United Kingdom.
Colin J HendersonDivision of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, United Kingdom.
Marie StiborovaDepartment of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.
David H PhillipsDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, London, United Kingdom.
Volker M ArltDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, London, United Kingdom. Electronic address: volker.arlt@kcl.ac.uk.
Charles University · CZKing's College London · GBUniversity of Dundee · GBGerman Cancer Research Center · DE

Funding

Cancer Research UK 14329Cancer Research UK 15709Cancer Research UK 22357Wellcome Trust
6 · The paper itself

Abstract

The anticancer drug ellipticine exerts its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes. The present study has examined the role of cytochrome P450 oxidoreductase (POR) and cytochrome b

Indexed as

Activation, MetabolicAnimalsAntineoplastic AgentsAryl Hydrocarbon HydroxylasesCytochrome-B(5) ReductaseCytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemCytochromes b5DNA AdductsEllipticinesGenotypeHepatocytesLiverMembrane ProteinsMice, Inbred C57BLMice, KnockoutAntineoplastic AgentsAryl Hydrocarbon HydroxylasesCyp3a11 protein, mouseCytochrome-B(5) ReductaseCytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemCytochromes b5DNA AdductsellipticineEllipticinesMembrane ProteinsNADPH-Ferrihemoprotein ReductaseCytochrome b(5)Cytochrome P450DNA AdductsMetabolismMouse models

Identifiers

PMID30685480
PMCPMC6382462
OpenAlexW2913657543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.