Evidence map›Paper›PMID 30685438›Full record

ArticleThe ocular surface2019

Expression of BK channels and Na

János Almássy, Gyula Diszházi, Marianna Skaliczki, Ildikó Márton, Zsuzsanna Édua Magyar, Péter P Nánási, David I Yule

Open access · greenAbstract read
In one paragraph

Article in The ocular surface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Ocular Surface Ion Transport and Dry Eye Disease.Current ophthalmology reports · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

János AlmássyDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address: almassy.janos@med.unideb.hu.
Gyula DiszháziDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Marianna SkaliczkiDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Dentistry, University of Debrecen, Debrecen, Hungary.
Ildikó MártonDepartment of Dentistry, University of Debrecen, Debrecen, Hungary.
Zsuzsanna Édua MagyarDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Péter P NánásiDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
David I YuleDepartment of Pharmacology and Physiology and the Centre for Oral Biology, University of Rochester, Medical Center, Rochester, USA.
University of Debrecen · HUUniversity of Rochester Medical Center · US

Funding

[Ca2+]i and Secretory Dynamics in Parotid Acinar CellsR01DE014756 · NIDCR · UNIVERSITY OF ROCHESTER · PI David I Yule · 2002 to 2026
$9.9M
An experimental/computational approach for understanding salivary fluid secretionR01DE019245 · NIDCR · UNIVERSITY OF ROCHESTER · PI David I Yule · 2008 to 2026
$9.7M
NIDCR NIH HHS R01 DE014756NIDCR NIH HHS R01 DE019245
6 · The paper itself

Abstract

purposePrimary fluid secretion in secretory epithelia relies on the unidirectional transport of ions and water across a single cell layer. This mechanism requires the asymmetric apico-basal distribution of ion transporters and intracellular Ca

methodsWhole-cell patch-clamp-electrophysiology, spatially localized flash-photolysis of Ca

resultsWe show that the Ca

conclusionsBased on these results we propose a new primary fluid-secretion model in the lacrimal gland, in which the paracellular pathway of Na

Indexed as

AnimalsImmunohistochemistryLacrimal ApparatusLarge-Conductance Calcium-Activated Potassium ChannelsMiceModels, AnimalPatch-Clamp TechniquesTearsLarge-Conductance Calcium-Activated Potassium ChannelsAcinar cellBK channelFluid secretionLacrimal glandmaxiKNa(+)-K(+) ATP-aseTear

Identifiers

PMID30685438
PMCPMC6529268
OpenAlexW2913346507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.