ArticleEBioMedicine2019
Among older adults, age-related changes in the stool microbiome differ by HIV-1 serostatus.
Article in EBioMedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Randomized, Placebo-Controlled Trial of Rifaximin Therapy for Lowering Gut-Derived Cardiovascular Toxins and Inflammation in CKD.Kidney360 · 2020Trial
- Interplay between viral infections and gut microbiota dysbiosis: Mechanisms and therapeutic potential.World journal of gastroenterology · 2026Review
- Healthy Aging and the Gut Microbiome in People With and Without HIV.The Journal of infectious diseases · 2025Article
- Article
- Aging and HIV: Recent Findings in Contributing Factors.AIDS research and treatment · 2025Review
- Clinical and Microbial Determinants of Upper Respiratory Colonization With Streptococcus pneumoniae and Native Microbiota in People With Human Immunodeficiency Virus Type 1 and Control Adults.The Journal of infectious diseases · 2024Article
- Exploring potential associations between the human microbiota and reservoir of latent HIV.Retrovirology · 2024Review
- Review
- The Gut and the Translocated Microbiomes in HIV Infection: Current Concepts and Future Avenues.Pathogens & immunity · 2024Review
- Impaired gut microbiota-mediated short-chain fatty acid production precedes morbidity and mortality in people with HIV.Cell reports · 2023Article
- Decrypting biological hallmarks of aging in people with HIV.Current opinion in HIV and AIDS · 2023Review
- Therapeutically targeting the consequences of HIV-1-associated gastrointestinal dysbiosis: Implications for neurocognitive and affective alterations.Pharmacology, biochemistry, and behavior · 2023Article
- The Gut Microbiome, Microbial Metabolites, and Cardiovascular Disease in People Living with HIV.Current HIV/AIDS reports · 2023Review
- Discrete patterns of microbiome variability across timescales in a wild rodent population.BMC microbiology · 2023Article
- The altered metabolites contributed by dysbiosis of gut microbiota are associated with microbial translocation and immune activation during HIV infection.Frontiers in immunology · 2022Article
- A Unique Gut Microbiome-Physical Function Axis Exists in Older People with HIV: An Exploratory Study.AIDS research and human retroviruses · 2021Article
- Review
- The gut microbiome and frailty.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Review on the Alteration of Gut Microbiota: The Role of HIV Infection and Old Age.AIDS research and human retroviruses · 2020Review
- Obese Adolescents With PCOS Have Altered Biodiversity and Relative Abundance in Gastrointestinal Microbiota.The Journal of clinical endocrinology and metabolism · 2020Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundHIV-1 infection and physiological aging are independently linked to elevated systemic inflammation and changes in enteric microbial communities (dysbiosis). However, knowledge of the direct effect of HIV infection on the aging microbiome and potential links to systemic inflammation is lacking.
methodsIn a cross-sectional study of older people living with HIV (PLWH) (median age 61.5 years, N = 14) and uninfected controls (median 58 years, n = 22) we compared stool microbiota, levels of microbial metabolites (short-chain fatty acid levels, SCFA) and systemic inflammatory biomarkers by HIV serostatus and age.
findingsHIV and age were independently associated with distinct changes in the stool microbiome. For example, abundances of Enterobacter and Paraprevotella were higher and Eggerthella and Roseburia lower among PLWH compared to uninfected controls. Age-related microbiome changes also differed by HIV serostatus. Some bacteria with inflammatory potential (e.g. Escherichia) increased with age among PLWH, but not controls. Stool SCFA levels were similar between the two groups yet patterns of associations between individual microbial taxa and SCFA levels differed. Abundance of various genera including Escherichia and Bifidobacterium positively associated with inflammatory biomarkers (e.g. soluble Tumor Necrosis Factor Receptors) among PLWH, but not among controls.
interpretationThe age effect on the gut microbiome and associations between microbiota and microbial metabolites or systemic inflammation differed based on HIV serostatus, raising important implications for the impact of therapeutic interventions, dependent on HIV serostatus or age.
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