Evidence map›Paper›PMID 30685329›Full record

SynthesisNeuroImage2019

Magnetoencephalography and the infant brain.

Yu-Han Chen, Joni Saby, Emily Kuschner, William Gaetz, J Christopher Edgar, Timothy P L Roberts

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Critical Review on the Development and Evolution of Beat Perception.Annals of the New York Academy of Sciences · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Functional and structural maturation of auditory cortex from 2 months to 2 years old.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Article
  13. Review
  14. From behavioral synchrony to language and beyond.Frontiers in integrative neuroscience · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yu-Han ChenLurie Family Foundations MEG Imaging Center, Dept. of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Joni SabyLurie Family Foundations MEG Imaging Center, Dept. of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Emily KuschnerLurie Family Foundations MEG Imaging Center, Dept. of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
William GaetzLurie Family Foundations MEG Imaging Center, Dept. of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
J Christopher EdgarLurie Family Foundations MEG Imaging Center, Dept. of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Timothy P L RobertsLurie Family Foundations MEG Imaging Center, Dept. of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. Electronic address: robertstim@email.chop.edu.
Children's Hospital of Philadelphia · USImaging Center · US

Funding

A longitudinal study of brain development in children with autismR01MH107506 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI James Christopher EDGAR · 2016 to 2026
$7.5M
The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBINSON, MICHAEL BYRNE, SCHULTZ, ROBERT THOMAS · 2016 to 2020
$6.3M
Brain structure and function in infantsR01HD093776 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI James Christopher EDGAR · 2018 to 2026
$5.7M
Electrophysiological Signatures of Language Impairment in Autism Spectrum DisordeR01DC008871 · NIDCD · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBERTS, TIMOTHY P · 2007 to 2018
$3.6M
Development of infant brain MEG responses to social stimuli: comparison to ASDK01MH108822 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI CHEN, YU-HAN · 2015 to 2019
$881k
NICHD NIH HHS R01 HD093776NICHD NIH HHS U54 HD086984NIDCD NIH HHS R01 DC008871NIMH NIH HHS K01 MH108822NIMH NIH HHS R01 MH107506
6 · The paper itself

Abstract

Magnetoencephalography (MEG) is a non-invasive neuroimaging technique that provides whole-head measures of neural activity with millisecond temporal resolution. Over the last three decades, MEG has been used for assessing brain activity, most commonly in adults. MEG has been used less often to examine neural function during early development, in large part due to the fact that infant whole-head MEG systems have only recently been developed. In this review, an overview of infant MEG studies is provided, focusing on the period from birth to three years. The advantages of MEG for measuring neural activity in infants are highlighted (See Box 1), including the ability to assess activity in brain (source) space rather than sensor space, thus allowing direct assessment of neural generator activity. Recent advances in MEG hardware and source analysis are also discussed. As the review indicates, efforts in this area demonstrate that MEG is a promising technology for studying the infant brain. As a noninvasive technology, with emerging hardware providing the necessary sensitivity, an expected deliverable is the capability for longitudinal infant MEG studies evaluating the developmental trajectory (maturation) of neural activity. It is expected that departures from neuro-typical trajectories will offer early detection and prognosis insights in infants and toddlers at-risk for neurodevelopmental disorders, thus paving the way for early targeted interventions.

Indexed as

Functional NeuroimagingMagnetoencephalographyBrainEvoked PotentialsHumansInfantAuditoryDevelopmentInfantMEGSomatosensoryVisual

Identifiers

PMID30685329
PMCPMC6662211
OpenAlexW2911878572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.