Evidence map›Paper›PMID 30685253›Full record

ReviewArchives of biochemistry and biophysics2019

SR-mitochondria communication in adult cardiomyocytes: A close relationship where the Ca

Sergio De la Fuente, Shey-Shing Sheu

Abstract readReview
In one paragraph

Review in Archives of biochemistry and biophysics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Nonstructural Roles of Junctophilin-2 in the Heart.JACC. Basic to translational science · 2025
    Review
  5. Article
  6. Review
  7. Mitochondrial dysfunction as a central hub linking NaFrontiers in cardiovascular medicine · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Disruption of mitochondria-sarcoplasmic reticulum microdomain connectomics contributes to sinus node dysfunction in heart failure.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Neurohormonal connections with mitochondria in cardiomyopathy and other diseases.American journal of physiology. Cell physiology · 2022
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sergio De la FuenteCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, 19107, USA. Electronic address: Sergiodelafuente.perez@jefferson.edu.
Shey-Shing SheuCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, 19107, USA. Electronic address: shey-shing.sheu@jefferson.edu.

Funding

Ca2+ and ROS Crosstalk Signaling in Cardiac MitochondriaR01HL093671 · NHLBI · UNIVERSITY OF ROCHESTER · PI SHEU, SHEY-SHING · 2010 to 2023
$5.1M
Mitochondria-SR Tethering: Its Role in Cardiac Bioenergetics and Ca2+ DynamicsR01HL122124 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, SHEU, SHEY-SHING · 2014 to 2025
$4.0M
Dynamin-Related Protein Drp1 Regulates Cardiac Excitation-Contraction-Bioenergetics CouplingR01HL137266 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI SHEU, SHEY-SHING, WANG, WANG · 2018 to 2021
$2.5M
Structural-functional zoning of the mitochondrion in cardiac Ca2+, ROS, and energetics regulationR01HL142864 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, SHEU, SHEY-SHING · 2018 to 2021
$2.5M
Trpm2: A novel target in Onco-cardiologyR01HL137426 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CHEUNG, JOSEPH Y · 2017 to 2020
$2.2M
Vevo 2100 ultrasound scannerS10OD010408 · OD · THOMAS JEFFERSON UNIVERSITY · PI FORSBERG, FLEMMING · 2012 to 2012
$525k
NHLBI NIH HHS R01 HL093671NHLBI NIH HHS R01 HL122124NHLBI NIH HHS R01 HL137266NHLBI NIH HHS R01 HL137426NHLBI NIH HHS R01 HL142864NIH HHS S10 OD010408
6 · The paper itself

Abstract

In adult cardiomyocytes, T-tubules, junctional sarcoplasmic reticulum (jSR), and mitochondria juxtapose each other and form a unique and highly repetitive functional structure along the cell. The close apposition between jSR and mitochondria creates high Ca

Indexed as

AdultCalciumCalcium SignalingHumansMitochondria, HeartMitochondrial DynamicsMyocytes, CardiacSarcoplasmic ReticulumCalciumCalciumHeartMitochondriaMitochondrial Ca(2+) uniporterMitofusin 2SR-Mitochondria contacts

Identifiers

PMID30685253
PMCPMC6377816

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.