Evidence map›Paper›PMID 30684471›Full record

SynthesisContraception2019

Altered pharmacokinetics of combined oral contraceptives in obesity - multistudy assessment.

Dandan Luo, Carolyn L Westhoff, Alison B Edelman, Melissa Natavio, Frank Z Stanczyk, William J Jusko

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Contraception, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Dandan LuoDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA; Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA.
Carolyn L WesthoffDepartment of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10032, USA.
Alison B EdelmanDepartment of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR 97239, USA.
Melissa NatavioDepartment of Obstetrics and Gynecology, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
Frank Z StanczykDepartment of Obstetrics and Gynecology, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
William J JuskoDepartment of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA. Electronic address: wjjusko@buffalo.edu.
University at Buffalo, State University of New York · USUniversity of Southern California · USColumbia University Irving Medical Center · USOregon Health & Science University · US

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
YOUTH, Osteoporosis, and Understanding Total Health (YOUTH)M01RR000334 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI DORSA, DANIEL MICHAEL · 1985 to 2006
$30.6M
Corticosteroid Pharmacokinetics and PharmacodynamicsR37GM024211 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI JUSKO, WILLIAM J. · 2005 to 2014
$6.4M
CORTICOSTEROID PHARMACOKINETICS/DYNAMICSR01GM024211 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI JUSKO, WILLIAM J. · 1985 to 2018
$4.7M
WOMENS REPRODUCTIVE HEALTH RESEARCH CAREER DEVELOPMENTK12HD001243 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI BURRY, KENNETH A · 1998 to 2008
$3.1M
Improving Contraceptive Effectiveness in Obese WomenR01HD061582 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI EDELMAN, ALISON B · 2009 to 2010
$1.1M
Inflammatory cytokine-mediated induction of HIV cardiomyopathyK01RR024120 · NCRR · HARVARD MEDICAL SCHOOL · PI YEARLEY, JENNIFER · 2007 to 2008
$246k
Contraceptive efficacy and body weight: Does obesity affect the risk of failure?R03HD053611 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI EDELMAN, ALISON B · 2006 to 2007
$127k
NCATS NIH HHS UL1 TR002369NCRR NIH HHS K01 RR024120NCRR NIH HHS M01 RR000334NCRR NIH HHS UL1 RR024156NICHD NIH HHS K12 HD001243NICHD NIH HHS R01 HD061582NICHD NIH HHS R03 HD053611NIGMS NIH HHS R01 GM024211NIGMS NIH HHS R37 GM024211
6 · The paper itself

Abstract

objectiveThe objective was to evaluate the pharmacokinetics (PKs) of levonorgestrel (LNG)-containing combined oral contraceptives (COCs) in obese women. STUDY

designWe pooled and reanalyzed data from 89 women with different body mass index (BMI) categories from four clinical studies. The LNG and ethinyl estradiol (EE) PKs were analyzed utilizing a zero-order absorption (K

resultsIncreasing of body habitus metrics is correlated with decreasing C

conclusionsThe primary effects of obesity on LNG and EE were a modest increase in CL and a marked increase in distribution parameters. We observed no obesity-related differences in trough LNG and EE concentrations. IMPLICATIONS: This population PK analysis demonstrated reduced systemic exposure to LNG/EE oral contraceptives in obese subjects (C

Indexed as

Clinical Studies as TopicContraceptives, Oral, CombinedEthinyl EstradiolHumansLevonorgestrelObesityContraceptives, Oral, CombinedEthinyl EstradiolLevonorgestrelClearanceCombined oral contraceptivesObesityPharmacokineticsVolume of distribution

Identifiers

PMID30684471
PMCPMC6441376
OpenAlexW2913913252

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.