Evidence map›Paper›PMID 30684392›Full record

ArticleInternational journal of cancer2019

Neonatal phototherapy and future risk of childhood cancer.

Nathalie Auger, Caroline Laverdière, Aimina Ayoub, Ernest Lo, Thuy Mai Luu

Registry-linked trialOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in International journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07674537 (Bilirubin Thresholds in Preterm Infants on Neonatal Intensive CarE Units), which is not on this map. Cited by 19 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 7 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07674537 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Bilirubin Thresholds in Preterm Infants on Neonatal Intensive CarE Units: The B-NICE Trial

TypeinterventionalSponsorUniversity Medical Center GroningenRan2026 to 2029Enrolled680ConditionsNeonatal Hyperbilirubinemia, Treatment Decisions, Neurodevelopmental Outcome, PhototherapyArmsPhototherapy, Exchange Transfusion
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 7 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  8. Article
  9. Review
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  11. What is the minimum duration of cycled phototherapy that is still effective in treating hyperbilirubinemia?Journal of perinatology : official journal of the California Perinatal Association · 2023
    Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Blinded by the light? Possible phototherapy downsides.Journal of perinatology : official journal of the California Perinatal Association · 2020
    Article
  18. Phototherapy and childhood cancer: Shared risk factors.International journal of cancer · 2020
    Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Nathalie AugerUniversity of Montreal Hospital Research Centre, Montreal, QC, Canada.ORCID 0000-0002-2412-0459
Caroline LaverdièreDivision of Hematology and Oncology, Department of Pediatrics, Sainte-Justine University Hospital Centre, University of Montreal, Montreal, QC, Canada.
Aimina AyoubUniversity of Montreal Hospital Research Centre, Montreal, QC, Canada.
Ernest LoInstitut national de santé publique du Québec, Montreal, QC, Canada.
Thuy Mai LuuDivision of General Pediatrics, Department of Pediatrics, Sainte-Justine University Hospital Centre, University of Montreal, Montreal, QC, Canada.
Centre Hospitalier Universitaire Sainte-Justine · CAMcGill University Health Centre · CAInstitut National de Santé Publique du Québec · CA

Funding

CIHR PCC-156725
6 · The paper itself

Abstract

We sought to determine if neonatal phototherapy is associated with a greater risk of childhood cancer. We conducted a retrospective cohort study of 786,998 infants born in hospitals of Quebec, Canada between 2006 and 2016, with 4,660,868 person-years of follow-up over an 11-year period. The exposures were neonatal phototherapy (32,314 or 4.1% of infants) and untreated jaundice (91,855 or 11.7% of infants). The outcome was hospitalization for solid or hematopoietic childhood tumours between 2 months and 11 years of age. We used Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (CI) for the association of phototherapy with childhood cancer, adjusted for infant characteristics. The incidence of childhood cancer was higher for infants with phototherapy (25.1 per 100,000 person-years) and untreated jaundice (23.0 per 100,000) compared to unexposed infants (21.6 per 100,000). Phototherapy appeared to be associated with late onset solid tumours, including brain/central nervous system cancers. Between age 4 and 11 years, children who received neonatal phototherapy had more than 2 times the risk of any solid tumour compared to unexposed children (HR 2.26, 95% CI 1.34-3.81). Results were similar for phototherapy compared against untreated jaundice. A similar trend was however less apparent for hematopoietic cancer. We conclude that neonatal phototherapy may be associated with a slightly increased risk of solid tumours in childhood, but cannot rule out an effect of bilirubin. Minimizing unnecessary exposure to phototherapy through adherence to recommended thresholds for treatment is encouraged.

Indexed as

CanadaChildChild, PreschoolFemaleHospitalizationHumansIncidenceInfantInfant, NewbornJaundiceMaleNeoplasmsPhototherapyProportional Hazards ModelsRetrospective Studiescentral nervous system neoplasmshyperbilirubinemiajaundice, neonatalneoplasmsphototherapy

Identifiers

PMID30684392
OpenAlexW2911873235

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.