Evidence map›Paper›PMID 30684388›Full record

ArticleInternational journal of cancer2019

DNMT3a-triggered downregulation of K

Qingxiang Mao, Shaogen Wu, Xiyao Gu, Shibin Du, Kai Mo, Linlin Sun, Jing Cao, Alex Bekker, Liyong Chen, Yuan-Xiang Tao

Open access · bronzeAbstract read
In one paragraph

Article in International journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. RNA-binding protein MBNL2 mitigates neuropathic pain after chemotherapy through destabilizing CCR2 expression in primary sensory neurons.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Fibroblast growth factor 3 contributes to neuropathic pain through Akt/mTOR signaling in mouse primary sensory neurons.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Article
  20. Epigenetic Landscapes of Pain: DNA Methylation Dynamics in Chronic Pain.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Qingxiang MaoDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ.ORCID 0000-0002-9268-4846
Shaogen WuDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ.
Xiyao GuDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ.
Shibin DuDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ.
Kai MoDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ.
Linlin SunDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ.
Jing CaoDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ.
Alex BekkerDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ.
Liyong ChenDepartment of Anesthesiology, Daping Hospital, Institute of Surgery Research, Third Military Medical University (Army Medical University), Chongqing, China.
Yuan-Xiang TaoDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ.ORCID 0000-0003-1777-3272
Rutgers, The State University of New Jersey · USArmy Medical University · CN

Funding

The Role of Endothelin-1 in Sickle Cell DiseaseU01HL117684 · NHLBI · AUGUSTA UNIVERSITY · PI KUTLAR, ABDULLAH, MEILER, STEFFEN · 2013 to 2017
$8.1M
Dissection of a new spinal cord circuit in pain sensationR01NS094224 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LUO, WENQIN · 2016 to 2020
$2.5M
Epigenetic regulation of neuropathic pain: Role of DRG histone methyltransferase G9aR01NS094664 · NINDS · RBHS-NEW JERSEY MEDICAL SCHOOL · PI TAO, YUAN-XIANG · 2016 to 2020
$2.0M
mTOR, a new target for opioid-induced tolerance and hyperalgesiaR01DA033390 · NIDA · RBHS-NEW JERSEY MEDICAL SCHOOL · PI TAO, YUAN-XIANG · 2013 to 2017
$1.8M
NHLBI NIH HHS U01 HL117684NIDA NIH HHS R01 DA033390NINDS NIH HHS R01 NS094224NINDS NIH HHS R01 NS094664
6 · The paper itself

Abstract

Antineoplastic drugs induce dramatic transcriptional changes in dorsal root ganglion (DRG) neurons, which may contribute to chemotherapy-induced neuropathic pain. K

Indexed as

Down-RegulationAnimalsCells, CulturedDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3AGanglia, SpinalHumansHyperalgesiaMaleMice, KnockoutNeuralgiaPaclitaxelPatch-Clamp TechniquesPotassium Channels, Tandem Pore DomainRNA InterferenceDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanDnmt3a protein, mouseKcnk1 protein, mousePaclitaxelPotassium Channels, Tandem Pore DomainDNMT3adorsal root ganglionK2p1.1neuropathic painpaclitaxel

Identifiers

PMID30684388
PMCPMC6660426
OpenAlexW2914934100

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.