Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
Value of intraventricular dyssynchrony assessment by gated-SPECT myocardial perfusion imaging in the management of heart failure patients undergoing cardiac resynchronization therapy (VISION-CRT).
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- A New Method of Modeling the Multi-stage Decision-Making Process of CRT Using Machine Learning with Uncertainty Quantification.Journal of imaging informatics in medicine · 2026Article
- A New Method Using Deep Learning to Predict the Response to Cardiac Resynchronization Therapy.Journal of imaging informatics in medicine · 2025Article
- Clinical phenotypes among patients that underwent cardiac resynchronization therapy using unsupervised learning integrating gated SPECT.Nuclear medicine communications · 2025Article
- A Prospective Pilot Study for Prognosis of Cardiac Resynchronization Therapy Super-Response Using Electrical and Mechanical Dyssynchrony Assessment in Patients with Heart Failure and Strauss Left Bundle Branch Block Criteria.Life (Basel, Switzerland) · 2025Article
- A predictive model of super response to cardiac resynchronization therapy in short-term period.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- The influence of arm positions on mechanical dyssynchrony measured by gated myocardial perfusion imaging.Quantitative imaging in medicine and surgery · 2023Article
- A machine learning method integrating ECG and gated SPECT for cardiac resynchronization therapy decision support.European journal of nuclear medicine and molecular imaging · 2023Article
- Left ventricular mechanical dyssnchrony: A potential new marker for 3-vessel CAD.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Nuclear Cardiology in the Optimization of Resynchronization Therapy: Quo Vadis?Arquivos brasileiros de cardiologia · 2023Article
- The Value of Left Ventricular Mechanical Dyssynchrony and Scar Burden in the Combined Assessment of Factors Associated with Cardiac Resynchronization Therapy Response in Patients with CRT-D.Journal of clinical medicine · 2023Article
- The value of cardiac sympathetic activity and mechanical dyssynchrony as cardiac resynchronization therapy response predictors: comparison between patients with ischemic and non-ischemic heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- A method using deep learning to discover new predictors from left-ventricular mechanical dyssynchrony for CRT response.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prediction of Cardiac Resynchronization Therapy Response Using Quantitative Gated Myocardial Perfusion Imaging.The Journal of innovations in cardiac rhythm management · 2023Article
- Predictive values of left ventricular mechanical dyssynchrony for CRT response in heart failure patients with different pathophysiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Incremental value of left ventricular shape parameters measured by gated SPECT MPI in predicting the super-response to CRT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Mechanical dyssynchrony: How do we measure it, what it means, and what we can do about it.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Left-ventricular dyssynchrony in viable myocardium by myocardial perfusion SPECT is predictive of mechanical response to CRT.Annals of nuclear medicine · 2021Article
- Diastolic dyssynchrony assessment by gated myocardial perfusion-SPECT in subjects who underwent cardiac resynchronization therapy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Left ventricular systolic and diastolic dyssynchrony to improve cardiac resynchronization therapy response in heart failure patients with dilated cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Technical aspects of gated SPECT MPI assessment of left ventricular dyssynchrony used in the VISION-CRT study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
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15 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPlacing the left ventricular (LV) lead in a viable segment with the latest mechanical activation (vSOLA) may be associated with optimal cardiac resynchronization therapy (CRT) response. We assessed the role of gated SPECT myocardial perfusion imaging (gSPECT MPI) in predicting clinical outcomes at 6 months in patients submitted to CRT.
methodsTen centers from 8 countries enrolled 195 consecutive patients. All underwent gSPECT MPI before and 6 months after CRT. The procedure was performed as per current guidelines, the operators being unaware of gSPECT MPI results. Regional LV dyssynchrony (Phase SD) and vSOLA were automatically determined using a 17 segment model. The lead was considered on-target if placed in vSOLA. The primary outcome was improvement in ≥1 of the following: ≥1 NYHA class, left ventricular ejection fraction (LVEF) by ≥5%, reduction in end-systolic volume by ≥15%, and ≥5 points in Minnesota Living With Heart Failure Questionnaire (MLHFQ).
resultsSixteen patients died before the follow-up gSPECT MPI. The primary outcome occurred in 152 out of 179 (84.9%) cases. Mean change in LV phase standard deviation (PSD) at 6 months was 10.5°. Baseline dyssynchrony was not associated with the primary outcome. However, change in LV PSD from baseline was associated with the primary outcome (OR 1.04, 95% CI 1.01-1.07, P = .007). Change in LV PSD had an AUC of 0.78 (0.66-0.90) for the primary outcome. Improvement in LV PSD of 4° resulted in the highest positive likelihood ratio of 7.4 for a favorable outcome. In 23% of the patients, the CRT lead was placed in the vSOLA, and in 42% in either this segment or in a segment within 10° of it. On-target lead placement was not significantly associated with the primary outcome (OR 1.53, 95% CI 0.71-3.28).
conclusionLV dyssynchrony improvement by gSPECT MPI, but not on-target lead placement, predicts clinical outcomes in patients undergoing CRT.
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