ReviewCurrent gastroenterology reports2019
The Microbiome-Host Interaction as a Potential Driver of Anastomotic Leak.
Review in Current gastroenterology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Optimizing quantitative fluorescence angiography for visceral perfusion assessment.Surgical endoscopy · 2020Pooled it
- The impact of enteral immunonutrition on gut microbiota in colorectal cancer and gastric cancer patients in the preoperative period-preliminary results of randomized clinical trial.Frontiers in immunology · 2025Trial
- Post-Surgical Gut Microbiota Alterations in Pediatric Patients with Intestinal Disorders.Journal of clinical medicine · 2026Review
- The gut microbiome in colorectal anastomotic leakage: from mechanisms to precision.Frontiers in medicine · 2026Review
- Pilot Study: Investigating the Local Breast Microbiome in Implant-based Breast Reconstruction Using 16S rRNA Sequencing.Plastic and reconstructive surgery. Global open · 2025Article
- Fusobacterium nucleatum promotes anastomotic leakage by activating epithelial cells through the NOD1/RIPK2/ERK signalling pathway to drive IL-1β-induced neutrophil chemotaxis and collagen degradation.Clinical and translational medicine · 2025Article
- Prediction of anastomotic insufficiency based on the mucosal microbiome prior to colorectal surgery: a proof-of-principle study.Scientific reports · 2024Article
- Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery.Gut microbes · 2023Article
- Metagenomics of microbiota following probiotic supplementation in rats subjected to intestinal anastomosis.Surgery open science · 2023Article
- Ileocolonic Healing after Small Ileocecal Resection in Mice: NOD2 Deficiency Impairs Anastomotic Healing by Local Mechanisms.Journal of clinical medicine · 2023Article
- The Influence of the Microbiome on Anastomotic Leak.Clinics in colon and rectal surgery · 2023Review
- The Colorectal Anastomosis: A Timeless Challenge.Clinics in colon and rectal surgery · 2023Review
- Alterations of gut microbiome following gastrointestinal surgical procedures and their potential complications.Frontiers in cellular and infection microbiology · 2023Review
- Acute and persistent effects of commonly used antibiotics on the gut microbiome and resistome in healthy adults.Cell reports · 2022Article
- Stem cell therapy applied for digestive anastomosis: Current state and future perspectives.World journal of stem cells · 2022Article
- An evaluation of short-term outcomes after reoperations for anastomotic leakage in colon cancer patients.International journal of colorectal disease · 2022Observational
- New understanding of gut microbiota and colorectal anastomosis leak: A collaborative review of the current concepts.Frontiers in cellular and infection microbiology · 2022Review
- The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets.Scientific reports · 2021Article
- Predictive and Diagnostic Biomarkers of Anastomotic Leakage: A Precision Medicine Approach for Colorectal Cancer Patients.Journal of personalized medicine · 2021Review
- Quantification of fluorescence angiography: Toward a reliable intraoperative assessment of tissue perfusion - A narrative review.Langenbeck's archives of surgery · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewThe goal of this paper is to review current literature on the gut microbiome within the context of host response to surgery and subsequent risk of developing complications, particularly anastomotic leak. We provide background on the relationship between host and gut microbiota with description of the role of the intestinal mucus layer as an important regulator of host health. RECENT
findingsDespite improvements in surgical technique and adherence to the tenets of creating a tension-free anastomosis with adequate blood flow, the surgical community has been unable to decrease rates of anastomotic leak using the current paradigm. Rather than adhere to empirical strategies of decontamination, it is imperative to focus on the interaction between the human host and the gut microbiota that live within us. The gut microbiome has been found to play a potential role in development of post-operative complications, including but not limited to anastomotic leak. Evidence suggests that peri-operative interventions may have a role in instigating or mitigating the impact of the gut microbiota via disruption of the protective mucus layer, use of multiple medications, and activation of virulence factors. The microbiome plays a potential role in the development of surgical complications and can be modulated by peri-operative interventions. As such, further research into this relationship is urgently needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.