Evidence map›Paper›PMID 30684117›Full record

ReviewCurrent HIV/AIDS reports2019

Medications for Treatment of Opioid Use Disorder among Persons Living with HIV.

Laura Fanucchi, Sandra A Springer, P Todd Korthuis

Abstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Pilot of Methadone for Recently Incarcerated People with Human Immunodeficiency Virus and Opioid Use in South Africa.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2025
    Article
  9. Article
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  11. Article
  12. Article
  13. Article
  14. HIV and Substance Use Disorders.Infectious disease clinics of North America · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Laura FanucchiDivision of Infectious Disease, University of Kentucky College of Medicine, 740 South Limestone, K512, Lexington, KY, 40536, USA. laura.fanucchi@uky.edu.
Sandra A SpringerDepartment of Internal Medicine, Section of Infectious Disease, Yale School of Medicine, New Haven, CT, USA.
P Todd KorthuisSection of Addiction Medicine, Oregon Health & Science University, Portland, OR, USA.
Oregon Health & Science University · USUniversity of Kentucky · USYale University · US

Funding

Western States Node of the National Drug Abuse Treatment Clinical Trials Network (TMS for CUD) UG1DA015815 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Keith N. Humphreys, Philip Todd Korthuis · 2015 to 2026
$24.6M
Oregon HIV/Hepatitis and Opioid Prevention and Engagement (OR-HOPE) Study Cost ExtensionUH3DA044831 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KORTHUIS, PHILIP TODD · 2019 to 2022
$4.0M
Buprenorphine to Improve HIV Care Engagement and Outcomes: A Randomized TrialR01DA037441 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KORTHUIS, PHILIP TODD · 2013 to 2018
$2.7M
Medication Assisted Therapy as a Conduit to Care for HIV+ CJS Populations TransitK02DA032322 · NIDA · YALE UNIVERSITY · PI SPRINGER, SANDRA ANN · 2011 to 2022
$1.3M
Oregon HIV/Hepatitis and Opioid Prevention and Engagement (OR-HOPE) StudyUG3DA044831 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KORTHUIS, PHILIP TODD · 2017 to 2018
$895k
NIDA NIH HHS K02 DA032322NIDA NIH HHS R01 DA037441NIDA NIH HHS UG1 DA015815NIDA NIH HHS UG3 DA044831NIDA NIH HHS UH3 DA044831
6 · The paper itself

Abstract

purpose of reviewRecent HIV outbreaks have occurred as a result of the current US opioid epidemic. Providing medications for opioid use disorder (MOUD) with methadone, buprenorphine, and extended-release naltrexone is essential to achieving optimal HIV treatment outcomes including viral suppression and retention in treatment. This review describes the pharmacology of MOUD with specific attention to interactions with antiretroviral therapy, and to the effect of MOUD on HIV treatment outcomes. RECENT

findingsMethadone and buprenorphine both improve HIV viral suppression, adherence to antiretroviral therapy, and overall mortality for persons with opioid use disorder (OUD). Extended-release naltrexone has been most extensively studied in persons with HIV leaving incarcerated settings, and improves HIV viral suppression in that context. Strategies that integrate MOUD and HIV treatment are crucial to optimize viral suppression. The differing pharmacokinetic and delivery characteristics of these MOUD offer diverse options. Given the chronic and relapsing nature of both HIV and OUD, long-term approaches are required.

Indexed as

BuprenorphineHIV InfectionsHumansMethadoneNaltrexoneOpioid-Related DisordersTreatment OutcomeBuprenorphineMethadoneNaltrexoneBuprenorphineExtended-release naltrexoneHIVMATMedication for opioid use disorderMethadoneOpioid addictionOpioid use disorders

Identifiers

PMID30684117
PMCPMC6420833
OpenAlexW2911350077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.