Evidence map›Paper›PMID 30684030›Full record

ReviewZeitschrift fur Rheumatologie2019

[Evidence-based treatment recommendations for familial Mediterranean fever : A joint statement by the Society for Pediatric and Adolescent Rheumatology and the German Society for Rheumatology].

T Kallinich, N Blank, T Braun, E Feist, U Kiltz, U Neudorf, P T Oommen, C Weseloh, H Wittkowski, J Braun

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Zeitschrift fur Rheumatologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. [An unusual cause for kidney transplantation].Innere Medizin (Heidelberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

T KallinichPädiatrie m.S. Pulmonologie und Immunologie, Universitätsmedizin Charité Berlin, Berlin, Deutschland.
N BlankRheumatologie, Universitätklinikum Heidelberg, Heidelberg, Deutschland.
T BraunInnere Medizin, Sankt-Gertrauden Krankenhaus, Berlin, Deutschland.
E FeistKlinik für Rheumatologie und Klinische Immunologie, Charité Universitätsmedizin-Berlin, Berlin, Deutschland.
U KiltzRheumazentrum Ruhrgebiet, Claudiusstr. 45, 44649, Herne, Deutschland.
U NeudorfZentrum für Kinder- und Jugendmedizin - Bereich Rheumatologie, Universität Essen, Essen, Deutschland.
P T OommenKlinik für Kinder-Onkologie, -Hämatologie und Klinische Immunologie, Zentrum für Kinder- und Jugendmedizin, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland.
C WeselohDeutsche Gesellschaft für Rheumatologie, Berlin, Deutschland.
H WittkowskiKlinik für pädiatrische Rheumatologie und Immunologie, Universitätsklinikum Münster, Münster, Deutschland.
J BraunRheumazentrum Ruhrgebiet, Claudiusstr. 45, 44649, Herne, Deutschland. juergen.braun@elisabethgruppe.de.
Charité - Universitätsmedizin Berlin · DEHeinrich Heine University Düsseldorf · DERheumazentrum Ruhrgebiet · DERuhr University Bochum · DESankt Gertrauden Krankenhaus · DEUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFamilial Mediterranean fever (FMF) in Germany is a rare, genetically linked disease of childhood and adolescence, which is characterized by recurrent febrile episodes and clinical signs of peritonitis, pleuritis and arthritis. Treatment with colchicine is effective and well-tolerated in the majority of patients; however, some patients do not sufficiently respond to this treatment or are intolerant to colchicine. For these patients first-line treatment with biologics which block interleukin-1 can be used.

objectiveThe aim was to formulate evidence-based treatment recommendations for patients with an insufficient response and intolerance to colchicine treatment.

methodsBased on a literature search and the European League Against Rheumatism (EULAR) recommendations on FMF from 2016 the appointed members of the Society for Pediatric and Adolescent Rheumatology (GKJR) and the German Society for Rheumatology (DGRh) convened to work out and form a consensus in a joint statement on evidence-based treatment recommendations on FMF.

resultsAfter intensive discussions all decisions were in concordance. A total of 5 superordinate principles and 10 recommendations were agreed upon. DISCUSSION: The joint activities of the GKJR and the DGRh were successfully concluded in a timely manner. The recommendations form a good basis for optimal treatment of all age groups of patients with FMF.

Indexed as

Familial Mediterranean FeverAdolescentChildColchicineGermanyHumansInterleukin-1RheumatologyColchicineInterleukin-1AmyloidosisBiologicsColchicineFever attacksInterleukin-1

Identifiers

PMID30684030
OpenAlexW3164261507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.