ArticlePediatric research2019
Maternal folic acid supplementation reduces the severity of cleft palate in Tgf-β
Article in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Clinical Approach to Cleft Lip and Palate with or Without Surgical Correction in Ten Brachycephalic Puppies.Veterinary sciences · 2025Article
- Alterations of senescence-associated markers in patients with non-syndromic cleft lip and palate.Scientific reports · 2024Article
- Alterations in DNA Methylation in Orofacial Clefts.International journal of molecular sciences · 2022Review
- Maternal Folic Acid Deficiency Is Associated to Developing Nasal and Palate Malformations in Mice.Nutrients · 2021Article
- Gestational folate deficiency alters embryonic gene expression and cell function.Differentiation; research in biological diversityArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCleft palate (CP) constitutes the most frequently seen orofacial cleft and is often associated with low folate status. Folate plays an essential role in the human body as a major coenzyme in one-carbon metabolism, including DNA synthesis, repair, and methylation. Whether the administration of isolated folic acid (FA) supplements prevents the CP caused by genetic mutations is unknown, as is its effect on the mechanisms leading to palate fusion.
methodsFA was administered to females from two different strains of transforming growth factor β
resultsFA supplementation significantly reduced CP severity and improved palatal shelf adhesion in both strains both in vivo and in vitro. Medial edge epithelium proliferation increased, and its differentiation was normalized as indicated by the presence and disposition of collagen IV, laminin, fibronectin, and cytokeratin-17.
conclusionsA maternal FA supplementation reduces the CP appearance by improving the mechanisms leading to palatal shelf adhesion.
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Registered trials
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