ArticlePediatric research2019
Irisin serum levels are positively correlated with bone mineral status in a population of healthy children.
Article in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Irisin on Muscle Quality in a Cohort of Charcot-Marie-Tooth Patients
BIODETECT_CP a Novel Combination of BIOchemical, DEnsitometric, TEChnological and Imaging Tools to Evaluate the Bone/muscle Unit Health in Children with Cerebral Palsy
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Protective role of irisin on bone in osteoporosis: a systematic review of rodent studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Pooled it
- The association between circulating irisin levels and osteoporosis in women: a systematic review and meta-analysis of observational studies.Frontiers in endocrinology · 2024Pooled it
- Sex specific effects of irisin on the skeleton.Bone research · 2026Review
- Irisin Concentrations in Children and Adolescent Cancer Survivors and Their Relation to Metabolic, Bone, and Reproductive Profile: A Pilot Case-Control Study.Journal of clinical medicine · 2025Article
- The reciprocity of skeletal muscle and bone: an evolving view from mechanical coupling, secretory crosstalk to stem cell exchange.Frontiers in physiology · 2024Review
- Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children.Medicina (Kaunas, Lithuania) · 2023Article
- Serum irisin levels and osteoporosis in patients with advanced chronic kidney disease and renal transplant recipients.International urology and nephrology · 2023Article
- Irisin Role in Chondrocyte 3D Culture Differentiation and Its Possible Applications.Pharmaceutics · 2023Article
- Elevated Expression of ADAM10 in Skeletal Muscle of Patients with Idiopathic Inflammatory Myopathies Could Be Responsible for FNDC5/Irisin Unbalance.International journal of molecular sciences · 2023Article
- The association of serum irisin with anthropometric, metabolic, and bone parameters in obese children and adolescents.Frontiers in endocrinology · 2023Article
- Serum Irisin level is associated with fall risk, muscle strength, and cortical porosity in postmenopausal women.Frontiers in endocrinology · 2023Article
- Musculoskeletal health in children and adolescents.Frontiers in pediatrics · 2023Review
- Irisin and Bone in Sickness and in Health: A Narrative Review of the Literature.Journal of clinical medicine · 2022Review
- Irisin as a predictor of bone metabolism in Han Chinese Young Men with pre-diabetic individuals.BMC endocrine disorders · 2022Article
- What Is the Relationship Between Body Mass Index, Sex Hormones, Leptin, and Irisin in Children and Adolescents? A Path Analysis.Frontiers in pediatrics · 2022Article
- The Association of Serum Irisin with Bone Mineral Density and Turnover Markers in New-Onset Type 2 Diabetic Patients.International journal of endocrinology · 2022Article
- Irisin Serum Levels and Skeletal Muscle Assessment in a Cohort of Charcot-Marie-Tooth Patients.Frontiers in endocrinology · 2022Article
- Effects of cheerleading practice on advanced glycation end products, areal bone mineral density, and physical fitness in female adolescents.Frontiers in physiology · 2022Article
- Irisin at the crossroads of inter-organ communications: Challenge and implications.Frontiers in endocrinology · 2022Review
- Muscle-bone axis in children with chronic kidney disease: current knowledge and future perspectives.Pediatric nephrology (Berlin, Germany) · 2021Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIrisin is a myokine secreted by skeletal muscle during physical activity. Irisin treatment increased cortical bone mineral density (BMD) in young healthy mice and restored bone and muscle mass loss in a mouse model of disuse-induced osteoporosis and muscular atrophy. In humans, Irisin was positively correlated with BMD in young athletes. Considering that the bone mass reached during childhood is one of the most important determinants of lifelong skeletal health, we sought to determine if Irisin levels were correlated with bone mineral status in children.
methodsIrisin and bone metabolic markers were quantified in sera and bone mineral status was evaluated by quantitative ultrasound in a population of 34 healthy children (9.82 ± 3.2 years).
resultsWe found that Irisin levels were positively correlated with the amplitude-dependent speed of sound Z-score (r = 0.305; p < 0.001), bone transmission time Z-score (r = 0.375; p < 0.001) and osteocalcin (r = 0.370; p < 0.001), and negatively with Dickkopf WNT Signaling Pathway Inhibitor 1 (r = -0.274; p < 0.001).
conclusionIn a regression analysis model, Irisin was one of the determinants of bone mineral status to a greater extent than bone alkaline phosphatase and parathyroid hormone, indicating that Irisin might be considered as one of the bone formation markers during childhood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.