ArticleThe ISME journal2019
T6SS contributes to gut microbiome invasion and killing of an herbivorous pest insect by plant-beneficial Pseudomonas protegens.
Article in The ISME journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 110 citations in OpenAlex.
- The insect- and plant-associated lifestyles of Pseudomonas protegens CHA0 are preserved following serial passage through insect larvae.PLoS pathogens · 2026Article
- From the leaf to the gut and back again: using synthetic bacterial communities to trace the fate and influence of phyllosphere bacteria in an Arabidopsis-Pieris brassicae system.Environmental microbiome · 2026Article
- From genome to lifestyle: adaptive strategies ofApplied and environmental microbiology · 2026Article
- Predicting bacterial-mediated entomopathogenicity through comparative genomics and statistical modeling.Microbiology spectrum · 2026Article
- Type VI secretion systems at the interface between bacteria and eukaryotic cells.Genetics and molecular biology · 2026Article
- From past to present: the crosstalk between type VI secretion system of Salmonella and host.Archives of microbiology · 2025Review
- Transcriptome-guided discovery of novel plant-associated genes in a rhizosphere Pseudomonas.Microbiome · 2025Article
- Silica nanoparticles suppress fungal pathogenic allies to alleviate Astragalus root rot.Microbiome · 2025Article
- Surface protein machineries in Gram-negative bacteria.Journal of cell science · 2025Review
- Maize Crops Under Rising Temperatures: Bacterial Influence on Biochemical and Lipidomic Changes Induced by Heat.Plants (Basel, Switzerland) · 2025Article
- Influence of the Origin, Feeding Status, andBiology · 2025Article
- The repressor PrtR1 and the global H-NS-like regulators MvaT and MvaV enable the fine-tuning of R-tailocin expression in Pseudomonas protegens.BMC microbiology · 2025Article
- Global biogeography and projection of antimicrobial toxin genes.Microbiome · 2025Article
- Soil microbiome bacteria protect plants against filamentous fungal infections via intercellular contacts.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Single nucleotide switches confer bacteriophage resistance tomicroLife · 2025Article
- TheISME communications · 2025Article
- Metabolites limiting predator growth wane with prey biodiversity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Enrichment of novel entomopathogenic Pseudomonas species enhances willow resistance to leaf beetles.Microbiome · 2024Article
- Article
- The role of the type VI secretion system in the stress resistance of plant-associated bacteria.Stress biology · 2024Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas protegens are multi-talented plant-colonizing bacteria that suppress plant pathogens and stimulate plant defenses. In addition, they are capable of invading and killing agriculturally important plant pest insects that makes them promising candidates for biocontrol applications. Here we assessed the role of type VI secretion system (T6SS) components of type strain CHA0 during interaction with larvae of the cabbage pest Pieris brassicae. We show that the T6SS core apparatus and two VgrG modules, encompassing the respective T6SS spikes (VgrG1a and VgrG1b) and associated effectors (RhsA and Ghh1), contribute significantly to insect pathogenicity of P. protegens in oral infection assays but not when bacteria are injected directly into the hemolymph. Monitoring of the colonization levels of P. protegens in the gut, hemolymph, and excrements of the insect larvae revealed that the invader relies on T6SS and VgrG1a module function to promote hemocoel invasion. A 16S metagenomic analysis demonstrated that T6SS-supported invasion by P. protegens induces significant changes in the insect gut microbiome affecting notably Enterobacteriaceae, a dominant group of the commensal gut bacteria. Our study supports the concept that pathogens deploy T6SS-based strategies to disrupt the commensal microbiota in order to promote host colonization and pathogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.